UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of
the Securities Exchange Act of 1934 (Amendment No.     )

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Filed by a Party other than the Registrant  o
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o	Preliminary Proxy Statement
o	Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))
o	Definitive Proxy Statement
x	Definitive Additional Materials
o	Soliciting Material under §240.14a-12
Prudential Investment Portfolios 16
(Name of Registrant as Specified In Its Charter)
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)
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PGIM QMA DEFENSIVE EQUITY FUND,

a series of Prudential Investment Portfolios 16

655 Broad Street

Newark, NJ  07102

We recently sent you proxy materials regarding the Special Meeting of Shareholders of PGIM QMA Defensive Equity Fund (formerly, Prudential QMA Defensive Equity Fund) (the “Defensive Equity Fund”), a series of Prudential Investment Portfolios 16 (“PIP 16”) scheduled to be held on Tuesday, October 16, 2018.   Our records indicate that we have not received your vote. We urge you to vote as soon as possible so we can obtain a sufficient number of votes to hold the meeting.  In the event that sufficient votes are not received, the persons named as proxies may propose one or more adjournments of the Meeting to permit further solicitation of proxies and this will result in further expenditures. By voting now you will help reduce the need for additional mailings and calls to shareholders.

Please Vote Today!

After careful review, the Board of Trustees has unanimously approved the proposal and recommends a vote “FOR” the proposal as detailed in your proxy statement. A copy of the proxy statement is available by calling the toll free number shown below.

You may think your vote is not important, but your participation is critical to hold the meeting, so please vote immediately.1-866-828-6951

Your vote is urgently needed! Please vote now to be sure it is received in time for the Fund’s October 16, 2018
Special Meeting of Shareholders. Voting takes only a few minutes. Thank you for your participation in this important matter. The Defensive Equity Fund has made it very easy for you to vote.  Choose one of the following methods: ·Speak to a proxy specialist by calling the number above. We can answer your questions and record your vote. (Open: M-F 8am – 10pm, Sat 11am – 5pm ET) ·Log on to the website noted on the enclosed proxy card and enter your control number printed on the card, and vote by following the on-screen prompts. ·Call the phone number on the enclosed proxy card: Enter the control number printed on the card and follow the touchtone prompts. ·Mail in your signed proxy card in the envelope provided.