0001752724-21-043917.txt : 20210226
0001752724-21-043917.hdr.sgml : 20210226
20210226163713
ACCESSION NUMBER: 0001752724-21-043917
CONFORMED SUBMISSION TYPE: NPORT-P
PUBLIC DOCUMENT COUNT: 1
CONFORMED PERIOD OF REPORT: 20201231
FILED AS OF DATE: 20210226
PERIOD START: 20210630
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SPDR SERIES TRUST
CENTRAL INDEX KEY: 0001064642
IRS NUMBER: 000000000
STATE OF INCORPORATION: MA
FILING VALUES:
FORM TYPE: NPORT-P
SEC ACT: 1940 Act
SEC FILE NUMBER: 811-08839
FILM NUMBER: 21689835
BUSINESS ADDRESS:
STREET 1: ONE LINCOLN STREET
CITY: BOSTON
STATE: MA
ZIP: 02111
BUSINESS PHONE: 617-664-1465
MAIL ADDRESS:
STREET 1: ONE LINCOLN STREET
CITY: BOSTON
STATE: MA
ZIP: 02111
FORMER COMPANY:
FORMER CONFORMED NAME: STREETTRACKS SERIES TRUST
DATE OF NAME CHANGE: 20000925
FORMER COMPANY:
FORMER CONFORMED NAME: INDEX EXCHANGE LISTED SECURITIES TRUST
DATE OF NAME CHANGE: 19980622
0001064642
S000010018
SPDR(R) S&P(R) Biotech ETF
C000027706
SPDR(R) S&P(R) Biotech ETF
XBI
NPORT-P
1
primary_doc.xml
NPORT-P
false
0001064642
XXXXXXXX
S000010018
C000027706
SPDR SERIES TRUST
811-08839
0001064642
5493004JVD6CQEEJSS37
One Iron Street
Boston
02210
617-664-8594
SPDR(R) S&P(R) Biotech ETF
S000010018
549300Y3ODFMPD5XXL58
2021-06-30
2020-12-31
N
8179624610.55
1138997841.74
7040626768.81
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
UST
Ionis Pharmaceuticals Inc
549300SI4ZGLG0BLUZ92
Ionis Pharmaceuticals Inc
462222100
1393124.00000000
NS
USD
78767230.96000000
1.118753110290
Long
EC
CORP
US
N
1
N
N
Generation Bio Co
N/A
Generation Bio Co
37148K100
332911.00000000
NS
USD
9438026.85000000
0.134050946881
Long
EC
CORP
US
N
1
N
N
Avrobio Inc
N/A
Avrobio Inc
05455M100
720713.00000000
NS
USD
10046739.22000000
0.142696659685
Long
EC
CORP
US
N
1
N
N
Ligand Pharmaceuticals Inc
5493008K7TB0IKP37H79
Ligand Pharmaceuticals Inc
53220K504
687449.00000000
NS
USD
68366803.05000000
0.971032910775
Long
EC
CORP
US
N
1
N
N
Clovis Oncology Inc
529900WCUY9ZAHMRV489
Clovis Oncology Inc
189464100
13158857.00000000
NS
USD
63162513.60000000
0.897114925617
Long
EC
CORP
US
N
1
N
N
Arrowhead Pharmaceuticals Inc
549300O3CSB8T7OZ3D66
Arrowhead Pharmaceuticals Inc
04280A100
861703.00000000
NS
USD
66118471.19000000
0.939099221718
Long
EC
CORP
US
N
1
N
N
Avita Therapeutics Inc
N/A
Avita Therapeutics Inc
05380C102
287007.00000000
NS
USD
5332590.06000000
0.075740274766
Long
EC
CORP
US
N
1
N
N
Protagonist Therapeutics Inc
N/A
Protagonist Therapeutics Inc
74366E102
949858.00000000
NS
USD
19149137.28000000
0.271980576570
Long
EC
CORP
US
N
1
N
N
Rhythm Pharmaceuticals Inc
529900JPNWXQ8DPLA551
Rhythm Pharmaceuticals Inc
76243J105
669468.00000000
NS
USD
19903283.64000000
0.282691929192
Long
EC
CORP
US
N
1
N
N
Alnylam Pharmaceuticals Inc
529900S3ZI14OWRJII50
Alnylam Pharmaceuticals Inc
02043Q107
492225.00000000
NS
USD
63974483.25000000
0.908647558672
Long
EC
CORP
US
N
1
N
N
N
Akebia Therapeutics Inc
549300CBQEHMKEEGNX42
Akebia Therapeutics Inc
00972D105
20129735.00000000
NS
USD
56363258.00000000
0.800543188139
Long
EC
CORP
US
N
1
N
N
Relay Therapeutics Inc
N/A
Relay Therapeutics Inc
75943R102
751006.00000000
NS
USD
31211809.36000000
0.443310097025
Long
EC
CORP
US
N
1
N
N
N
Kura Oncology Inc
5493005QORQTZCZYOP39
Kura Oncology Inc
50127T109
1533341.00000000
NS
USD
50078917.06000000
0.711284928237
Long
EC
CORP
US
N
1
N
N
Vertex Pharmaceuticals Inc
54930015RAQRRZ5ZGJ91
Vertex Pharmaceuticals Inc
92532F100
284664.00000000
NS
USD
67277489.76000000
0.955561088084
Long
EC
CORP
US
N
1
N
N
N
Translate Bio Inc
N/A
Translate Bio Inc
89374L104
1758104.00000000
NS
USD
32401856.72000000
0.460212674012
Long
EC
CORP
US
N
1
N
N
BioCryst Pharmaceuticals Inc
549300Z0INP1Z5NP6J59
BioCryst Pharmaceuticals Inc
09058V103
7691737.00000000
NS
USD
57303440.65000000
0.813896866453
Long
EC
CORP
US
N
1
N
N
N
Exact Sciences Corp
549300VM3X1FYD4N9Z14
Exact Sciences Corp
30063P105
492787.00000000
NS
USD
65289349.63000000
0.927322975267
Long
EC
CORP
US
N
1
N
N
Intercept Pharmaceuticals Inc
N/A
Intercept Pharmaceuticals Inc
45845P108
2078179.00000000
NS
USD
51331021.30000000
0.729068916525
Long
EC
CORP
US
N
1
N
N
Keros Therapeutics Inc
N/A
Keros Therapeutics Inc
492327101
210840.00000000
NS
USD
14872653.60000000
0.211240477422
Long
EC
CORP
US
N
1
N
N
Anika Therapeutics Inc
529900R9LS3Z0O6QH455
Anika Therapeutics Inc
035255108
319696.00000000
NS
USD
14469440.96000000
0.205513535017
Long
EC
CORP
US
N
1
N
N
Dicerna Pharmaceuticals Inc
549300CTZMJMPH28WN39
Dicerna Pharmaceuticals Inc
253031108
1538603.00000000
NS
USD
33895424.09000000
0.481426230973
Long
EC
CORP
US
N
1
N
N
G1 Therapeutics Inc
529900TC35UPZQYRKW13
G1 Therapeutics Inc
3621LQ109
1968354.00000000
NS
USD
35410688.46000000
0.502947956520
Long
EC
CORP
US
N
1
N
N
Catalyst Pharmaceuticals Inc
5299004O0R5XXLA5H544
Catalyst Pharmaceuticals Inc
14888U101
4147802.00000000
NS
USD
13853658.68000000
0.196767406296
Long
EC
CORP
US
N
1
N
N
AbbVie Inc
FR5LCKFTG8054YNNRU85
AbbVie Inc
00287Y109
600132.00000000
NS
USD
64304143.80000000
0.913329820078
Long
EC
CORP
US
N
1
N
N
N
Frequency Therapeutics Inc
N/A
Frequency Therapeutics Inc
35803L108
340207.00000000
NS
USD
11995698.82000000
0.170378280427
Long
EC
CORP
US
N
1
N
N
Myriad Genetics Inc
52990044IHUOUMETT163
Myriad Genetics Inc
62855J104
1402095.00000000
NS
USD
27726428.63000000
0.393806255329
Long
EC
CORP
US
N
1
N
N
ChemoCentryx Inc
529900YTTXUSFQTAKY40
ChemoCentryx Inc
16383L106
1051239.00000000
NS
USD
65092718.88000000
0.924530173483
Long
EC
CORP
US
N
1
N
N
Allovir Inc
N/A
Allovir Inc
019818103
463730.00000000
NS
USD
17825781.20000000
0.253184578381
Long
EC
CORP
US
N
1
N
N
N
BioMarin Pharmaceutical Inc
NSLL8ITTRR0J5HEMR848
BioMarin Pharmaceutical Inc
09061G101
802970.00000000
NS
USD
70412439.30000000
1.000087657137
Long
EC
CORP
US
N
1
N
N
Geron Corp
549300T282D7Z2YESL90
Geron Corp
374163103
8377273.00000000
NS
USD
13319864.07000000
0.189185771485
Long
EC
CORP
US
N
1
N
N
Eagle Pharmaceuticals Inc/DE
549300TN20OLYTJVP152
Eagle Pharmaceuticals Inc/DE
269796108
477113.00000000
NS
USD
22219152.41000000
0.315584863956
Long
EC
CORP
US
N
1
N
N
Spectrum Pharmaceuticals Inc
549300COU30WSP3O5I07
Spectrum Pharmaceuticals Inc
84763A108
6332961.00000000
NS
USD
21595397.01000000
0.306725490771
Long
EC
CORP
US
N
1
N
N
Sage Therapeutics Inc
5493000JX4BJS9W6CN35
Sage Therapeutics Inc
78667J108
924407.00000000
NS
USD
79970449.57000000
1.135842762241
Long
EC
CORP
US
N
1
N
N
CytomX Therapeutics Inc
5493004VW2FW0QLL3345
CytomX Therapeutics Inc
23284F105
1132098.00000000
NS
USD
7415241.90000000
0.105320763953
Long
EC
CORP
US
N
1
N
N
Beam Therapeutics Inc
N/A
Beam Therapeutics Inc
07373V105
741149.00000000
NS
USD
60507404.36000000
0.859403663151
Long
EC
CORP
US
N
1
N
N
LENSAR Inc
N/A
LENSAR Inc
52634L108
2385.00000000
NS
USD
17291.25000000
0.000245592481
Long
EC
CORP
US
N
1
N
N
N
Acceleron Pharma Inc
529900TQRID2UY164805
Acceleron Pharma Inc
00434H108
513543.00000000
NS
USD
65702691.42000000
0.933193784835
Long
EC
CORP
US
N
1
N
N
Seres Therapeutics Inc
549300GMXBE5NUWISF13
Seres Therapeutics Inc
81750R102
2621998.00000000
NS
USD
64238951.00000000
0.912403868425
Long
EC
CORP
US
N
1
N
N
Travere Therapeutics Inc
N/A
Travere Therapeutics Inc
89422G107
751034.00000000
NS
USD
20469431.67000000
0.290733088717
Long
EC
CORP
US
N
1
N
N
Vanda Pharmaceuticals Inc
529900AY8VOOQBKJ0O70
Vanda Pharmaceuticals Inc
921659108
1413558.00000000
NS
USD
18574152.12000000
0.263813900806
Long
EC
CORP
US
N
1
N
N
Y-mAbs Therapeutics Inc
N/A
Y-mAbs Therapeutics Inc
984241109
370548.00000000
NS
USD
18345831.48000000
0.260570998611
Long
EC
CORP
US
N
1
N
N
AnaptysBio Inc
529900HH4WQT03IG1A12
AnaptysBio Inc
032724106
794248.00000000
NS
USD
17076332.00000000
0.242539940842
Long
EC
CORP
US
N
1
N
N
Seagen Inc
N/A
Seagen Inc
81181C104
333825.00000000
NS
USD
58466110.50000000
0.830410592974
Long
EC
CORP
US
N
1
N
N
N
Invitae Corp
549300MYI59DZW1WIX92
Invitae Corp
46185L103
1127586.00000000
NS
USD
47144370.66000000
0.669604741283
Long
EC
CORP
US
N
1
N
N
Alector Inc
549300Z8RQOIY1JMHC25
Alector Inc
014442107
2198196.00000000
NS
USD
33258705.48000000
0.472382737675
Long
EC
CORP
US
N
1
N
N
Agios Pharmaceuticals Inc
529900ONJHY8EOGYT555
Agios Pharmaceuticals Inc
00847X104
1893147.00000000
NS
USD
82030059.51000000
1.165095980849
Long
EC
CORP
US
N
1
N
N
Esperion Therapeutics Inc
549300OFU56UKEWVUS92
Esperion Therapeutics Inc
29664W105
2044333.00000000
NS
USD
53152658.00000000
0.754942134348
Long
EC
CORP
US
N
1
N
N
Precigen Inc
549300XCWNQU35K64G19
Precigen Inc
74017N105
1693243.00000000
NS
USD
17271078.60000000
0.245305981514
Long
EC
CORP
US
N
1
N
N
Kadmon Holdings Inc
549300BBVICD23L50606
Kadmon Holdings Inc
48283N106
6735984.00000000
NS
USD
27954333.60000000
0.397043253646
Long
EC
CORP
US
N
1
N
N
Arcturus Therapeutics Holdings Inc
N/A
Arcturus Therapeutics Holdings Inc
03969T109
601985.00000000
NS
USD
26114109.30000000
0.370906030918
Long
EC
CORP
US
N
1
N
N
Intellia Therapeutics Inc
5493002T5BCPE5DZC723
Intellia Therapeutics Inc
45826J105
1198270.00000000
NS
USD
65185888.00000000
0.925853480669
Long
EC
CORP
US
N
1
N
N
N
Turning Point Therapeutics Inc
N/A
Turning Point Therapeutics Inc
90041T108
538094.00000000
NS
USD
65566753.90000000
0.931263026048
Long
EC
CORP
US
N
1
N
N
N
Halozyme Therapeutics Inc
529900242I3SV9AGM753
Halozyme Therapeutics Inc
40637H109
1554667.00000000
NS
USD
66399827.57000000
0.943095405428
Long
EC
CORP
US
N
1
N
N
Bluebird Bio Inc
N/A
Bluebird Bio Inc
09609G100
1503197.00000000
NS
USD
65043334.19000000
0.923828748857
Long
EC
CORP
US
N
1
N
N
Apellis Pharmaceuticals Inc
254900HS0ZFRXXSB9D42
Apellis Pharmaceuticals Inc
03753U106
1284209.00000000
NS
USD
73456754.80000000
1.043326925458
Long
EC
CORP
US
N
1
N
N
Biogen Inc
W8J5WZB5IY3K0NDQT671
Biogen Inc
09062X103
264357.00000000
NS
USD
64730455.02000000
0.919384838104
Long
EC
CORP
US
N
1
N
N
Madrigal Pharmaceuticals Inc
549300CHIMT2EUSNJB60
Madrigal Pharmaceuticals Inc
558868105
477405.00000000
NS
USD
53073113.85000000
0.753812346439
Long
EC
CORP
US
N
1
N
N
Ironwood Pharmaceuticals Inc
549300PC8MR6QHH6P296
Ironwood Pharmaceuticals Inc
46333X108
4533922.00000000
NS
USD
51641371.58000000
0.733476908743
Long
EC
CORP
US
N
1
N
N
United Therapeutics Corp
5299005C4HZL4UWROC14
United Therapeutics Corp
91307C102
460165.00000000
NS
USD
69848445.35000000
0.992077092616
Long
EC
CORP
US
N
1
N
N
N
Albireo Pharma Inc
549300835H8LC7O8VC29
Albireo Pharma Inc
01345P106
517126.00000000
NS
USD
19397396.26000000
0.275506668609
Long
EC
CORP
US
N
1
N
N
ACADIA Pharmaceuticals Inc
529900O3044NO0PEA039
ACADIA Pharmaceuticals Inc
004225108
1245125.00000000
NS
USD
66564382.50000000
0.945432625329
Long
EC
CORP
US
N
1
N
N
N
Viking Therapeutics Inc
529900IVC72YPFA25M37
Viking Therapeutics Inc
92686J106
3836299.00000000
NS
USD
21598363.37000000
0.306767622815
Long
EC
CORP
US
N
1
N
N
REVOLUTION Medicines Inc
549300JU3X0LBCQ65892
REVOLUTION Medicines Inc
76155X100
1098569.00000000
NS
USD
43492346.71000000
0.617734019117
Long
EC
CORP
US
N
1
N
N
Moderna Inc
549300EI6OKH5K5Q2G38
Moderna Inc
60770K107
406640.00000000
NS
USD
42481680.80000000
0.603379247259
Long
EC
CORP
US
N
1
N
N
N
Iovance Biotherapeutics Inc
549300220Z2GHH33XL82
Iovance Biotherapeutics Inc
462260100
1277644.00000000
NS
USD
59282681.60000000
0.842008581716
Long
EC
CORP
US
N
1
N
N
Mersana Therapeutics Inc
529900VWD5VDZ7PVOS22
Mersana Therapeutics Inc
59045L106
2127675.00000000
NS
USD
56617431.75000000
0.804153289318
Long
EC
CORP
US
N
1
N
N
Atreca Inc
549300B5CQV1OOXFLU71
Atreca Inc
04965G109
518670.00000000
NS
USD
8376520.50000000
0.118974073971
Long
EC
CORP
US
N
1
N
N
Celldex Therapeutics Inc
529900F018DMYWH38923
Celldex Therapeutics Inc
15117B202
1765613.00000000
NS
USD
30933539.76000000
0.439357755719
Long
EC
CORP
US
N
1
N
N
ImmunoGen Inc
54930084U0R1OP766Y02
ImmunoGen Inc
45253H101
5443761.00000000
NS
USD
35112258.45000000
0.498709271247
Long
EC
CORP
US
N
1
N
N
Twist Bioscience Corp
549300T23BL59LCOH584
Twist Bioscience Corp
90184D100
450537.00000000
NS
USD
63656372.73000000
0.904129345586
Long
EC
CORP
US
N
1
N
N
Enanta Pharmaceuticals Inc
529900SSN4DODDQSN594
Enanta Pharmaceuticals Inc
29251M106
563335.00000000
NS
USD
23716403.50000000
0.336850741826
Long
EC
CORP
US
N
1
N
N
Bioxcel Therapeutics Inc
549300Y25FYZ0E8LW260
Bioxcel Therapeutics Inc
09075P105
1480423.00000000
NS
USD
68395542.60000000
0.971441106678
Long
EC
CORP
US
N
1
N
N
Denali Therapeutics Inc
549300ZTQ2HO18L3Q830
Denali Therapeutics Inc
24823R105
797568.00000000
NS
USD
66804295.68000000
0.948840179626
Long
EC
CORP
US
N
1
N
N
Kiniksa Pharmaceuticals Ltd
N/A
Kiniksa Pharmaceuticals Ltd
000000000
1147840.00000000
NS
USD
20282332.80000000
0.288075670902
Long
EC
CORP
BM
N
1
N
N
Cardiff Oncology Inc
549300AHOLZBHHYFWP04
Cardiff Oncology Inc
14147L108
2588282.00000000
NS
USD
46563193.18000000
0.661350114257
Long
EC
CORP
US
N
1
N
N
Mirati Therapeutics Inc
529900GYRW59IDQV6N54
Mirati Therapeutics Inc
60468T105
267803.00000000
NS
USD
58820250.92000000
0.835440548852
Long
EC
CORP
US
N
1
N
N
N
Nkarta Inc
N/A
Nkarta Inc
65487U108
249147.00000000
NS
USD
15315066.09000000
0.217524186310
Long
EC
CORP
US
N
1
N
N
N
Five Prime Therapeutics Inc
549300Z652HXXGMB7V71
Five Prime Therapeutics Inc
33830X104
431911.00000000
NS
USD
7346806.11000000
0.104348751201
Long
EC
CORP
US
N
1
N
N
N
Akero Therapeutics Inc
549300SI3KG74LBE2955
Akero Therapeutics Inc
00973Y108
603990.00000000
NS
USD
15582942.00000000
0.221328903117
Long
EC
CORP
US
N
1
N
N
Inovio Pharmaceuticals Inc
529900B9W875XDZXTM97
Inovio Pharmaceuticals Inc
45773H201
5770452.00000000
NS
USD
51068500.20000000
0.725340255589
Long
EC
CORP
US
N
1
N
N
Vaxart Inc
N/A
Vaxart Inc
92243A200
8577988.00000000
NS
USD
48980311.48000000
0.695681124541
Long
EC
CORP
US
N
1
N
N
ZIOPHARM Oncology Inc
N/A
ZIOPHARM Oncology Inc
98973P101
4542142.00000000
NS
USD
11446197.84000000
0.162573563630
Long
EC
CORP
US
N
1
N
N
Precision BioSciences Inc
549300I5QGRS3BLHZH41
Precision BioSciences Inc
74019P108
1706126.00000000
NS
USD
14229090.84000000
0.202099774739
Long
EC
CORP
US
N
1
N
N
Incyte Corp
549300Z4WN6JVZ3T4680
Incyte Corp
45337C102
785078.00000000
NS
USD
68286084.44000000
0.969886441680
Long
EC
CORP
US
N
1
N
N
Krystal Biotech Inc
549300YONUY68210OE41
Krystal Biotech Inc
501147102
293981.00000000
NS
USD
17638860.00000000
0.250529684063
Long
EC
CORP
US
N
1
N
N
Fate Therapeutics Inc
549300L14Q4UHOODLA90
Fate Therapeutics Inc
31189P102
673656.00000000
NS
USD
61255540.08000000
0.870029644965
Long
EC
CORP
US
N
1
N
N
N
State Street Global Advisors
5493008BJIBKQ5KTIF74
State Street Navigator Securities Lending Government Money Market Portfolio
857492706
1086364528.25000000
NS
USD
1086364528.25000000
15.42994059935
Long
STIV
RF
US
N
1
N
N
TCR2 Therapeutics Inc
5493007TR1ORJAZ8YK34
TCR2 Therapeutics Inc
87808K106
524070.00000000
NS
USD
16209485.10000000
0.230227870788
Long
EC
CORP
US
N
1
N
N
Epizyme Inc
549300TNFWF88O4U4605
Epizyme Inc
29428V104
2661914.00000000
NS
USD
28908386.04000000
0.410593928484
Long
EC
CORP
US
N
1
N
N
Amgen Inc
62QBXGPJ34PQ72Z12S66
Amgen Inc
031162100
280662.00000000
NS
USD
64529807.04000000
0.916534978474
Long
EC
CORP
US
N
1
N
N
N
Adverum Biotechnologies Inc
529900ZEDOOZL1EWHJ89
Adverum Biotechnologies Inc
00773U108
2580147.00000000
NS
USD
27968793.48000000
0.397248631384
Long
EC
CORP
US
N
1
N
N
Karuna Therapeutics Inc
N/A
Karuna Therapeutics Inc
48576A100
481550.00000000
NS
USD
48920664.50000000
0.694833941726
Long
EC
CORP
US
N
1
N
N
Avidity Biosciences Inc
N/A
Avidity Biosciences Inc
05370A108
406091.00000000
NS
USD
10363442.32000000
0.147194882789
Long
EC
CORP
US
N
1
N
N
Allakos Inc
549300S6ZD1W6BPMDY37
Allakos Inc
01671P100
430678.00000000
NS
USD
60294920.00000000
0.856385688091
Long
EC
CORP
US
N
1
N
N
Cortexyme Inc
N/A
Cortexyme Inc
22053A107
547946.00000000
NS
USD
15221939.88000000
0.216201488586
Long
EC
CORP
US
N
1
N
N
Replimune Group Inc
549300AY704NEIRC4K64
Replimune Group Inc
76029N106
1160328.00000000
NS
USD
44266513.20000000
0.628729723269
Long
EC
CORP
US
N
1
N
N
N
IGM Biosciences Inc
5493008XCQES2N0VY969
IGM Biosciences Inc
449585108
428853.00000000
NS
USD
37863431.37000000
0.537784953148
Long
EC
CORP
US
N
1
N
N
Veracyte Inc
529900ESWZRHXOW27Z37
Veracyte Inc
92337F107
1065795.00000000
NS
USD
52160007.30000000
0.740843237580
Long
EC
CORP
US
N
1
N
N
Vaxcyte Inc
254900M7NMHTGASX8D95
Vaxcyte Inc
92243G108
617109.00000000
NS
USD
16396586.13000000
0.232885319282
Long
EC
CORP
US
N
1
N
N
Sorrento Therapeutics Inc
549300RH23PRR3M13410
Sorrento Therapeutics Inc
83587F202
8109411.00000000
NS
USD
55346730.08000000
0.786105156506
Long
EC
CORP
US
N
1
N
N
Blueprint Medicines Corp
5299004CC60O9T5HVM83
Blueprint Medicines Corp
09627Y109
556444.00000000
NS
USD
62405194.60000000
0.886358511098
Long
EC
CORP
US
N
1
N
N
N
Athenex Inc
5493001V4L0Q5EPPOH52
Athenex Inc
04685N103
2058343.00000000
NS
USD
22765273.58000000
0.323341576361
Long
EC
CORP
US
N
1
N
N
Rigel Pharmaceuticals Inc
529900KPTNUS5J8K9K66
Rigel Pharmaceuticals Inc
766559603
6097231.00000000
NS
USD
21340308.50000000
0.303102396998
Long
EC
CORP
US
N
1
N
N
CareDx Inc
549300NQOFKL9NON0U06
CareDx Inc
14167L103
925712.00000000
NS
USD
67067834.40000000
0.952583294105
Long
EC
CORP
US
N
1
N
N
Bridgebio Pharma Inc
54930028YG89VTY2J114
Bridgebio Pharma Inc
10806X102
1040277.00000000
NS
USD
73974097.47000000
1.050674888742
Long
EC
CORP
US
N
1
N
N
Kodiak Sciences Inc
254900IXI5NI8C9OQE24
Kodiak Sciences Inc
50015M109
507194.00000000
NS
USD
74511870.54000000
1.058313030738
Long
EC
CORP
US
N
1
N
N
MacroGenics Inc
5493001KJQUA83L8MH79
MacroGenics Inc
556099109
1538941.00000000
NS
USD
35180191.26000000
0.499674140033
Long
EC
CORP
US
N
1
N
N
N
Stoke Therapeutics Inc
549300RD25SS2DIJHJ67
Stoke Therapeutics Inc
86150R107
207839.00000000
NS
USD
12871469.27000000
0.182817094168
Long
EC
CORP
US
N
1
N
N
Dynavax Technologies Corp
549300T5URIXWDILX594
Dynavax Technologies Corp
268158201
9050172.00000000
NS
USD
40273265.40000000
0.572012502898
Long
EC
CORP
US
N
1
N
N
Cue Biopharma Inc
549300PBW78KZA33WC97
Cue Biopharma Inc
22978P106
900671.00000000
NS
USD
11267394.21000000
0.160033965440
Long
EC
CORP
US
N
1
N
N
Deciphera Pharmaceuticals Inc
529900QR4WAPYY0CBF25
Deciphera Pharmaceuticals Inc
24344T101
1119990.00000000
NS
USD
63917829.30000000
0.907842886703
Long
EC
CORP
US
N
1
N
N
IVERIC bio Inc
549300GZXI59U71XPM70
IVERIC bio Inc
46583P102
2059916.00000000
NS
USD
14234019.56000000
0.202169778734
Long
EC
CORP
US
N
1
N
N
N
Global Blood Therapeutics Inc
549300U4G0QKK99GRT15
Global Blood Therapeutics Inc
37890U108
1573198.00000000
NS
USD
68135205.38000000
0.967743464002
Long
EC
CORP
US
N
1
N
N
Athersys Inc
529900SJN2POLMMUAI78
Athersys Inc
04744L106
6103121.00000000
NS
USD
10680461.75000000
0.151697598817
Long
EC
CORP
US
N
1
N
N
Ardelyx Inc
549300F542QR4SXHCY32
Ardelyx Inc
039697107
1116530.00000000
NS
USD
7223949.10000000
0.102603778572
Long
EC
CORP
US
N
1
N
N
TG Therapeutics Inc
529900X21UKABN9NJ529
TG Therapeutics Inc
88322Q108
1509803.00000000
NS
USD
78539952.06000000
1.115525004221
Long
EC
CORP
US
N
1
N
N
Sarepta Therapeutics Inc
549300IKDPIED8J8IG21
Sarepta Therapeutics Inc
803607100
381590.00000000
NS
USD
65057279.10000000
0.924026812331
Long
EC
CORP
US
N
1
N
N
ACHILLION PHARMACE
529900LZPJ796VSWZM38
ACHILLION PHARMACE
004CVR031
51865.00000000
NS
USD
75463.58000000
0.001071830427
N/A
DE
US
N
2
N/A
N/A
Achillion Pharmaceuticals Inc
Achillion Pharmaceuticals Inc
2024-07-29
XXXX
51605.68000000
N
N
FibroGen Inc
549300Q914ULWWY95822
FibroGen Inc
31572Q808
1556229.00000000
NS
USD
57720533.61000000
0.819820954942
Long
EC
CORP
US
N
1
N
N
Gossamer Bio Inc
549300ZOC0N2W6PSFR58
Gossamer Bio Inc
38341P102
1712554.00000000
NS
USD
16560397.18000000
0.235211973646
Long
EC
CORP
US
N
1
N
N
Sangamo Therapeutics Inc
2549006WMRKRC4G32Z67
Sangamo Therapeutics Inc
800677106
4098136.00000000
NS
USD
63951412.28000000
0.908319875203
Long
EC
CORP
US
N
1
N
N
Puma Biotechnology Inc
N/A
Puma Biotechnology Inc
74587V107
1658852.00000000
NS
USD
17019821.52000000
0.241737306618
Long
EC
CORP
US
N
1
N
N
Heron Therapeutics Inc
549300DR2I1DOPD2IX53
Heron Therapeutics Inc
427746102
2318959.00000000
NS
USD
49080767.24000000
0.697107925922
Long
EC
CORP
US
N
1
N
N
Ultragenyx Pharmaceutical Inc
529900EV44GVDN1DCX77
Ultragenyx Pharmaceutical Inc
90400D108
440368.00000000
NS
USD
60960142.24000000
0.865834026454
Long
EC
CORP
US
N
1
N
N
Insmed Inc
529900Q55QAG41CCAC11
Insmed Inc
457669307
1599883.00000000
NS
USD
53260105.07000000
0.756468235270
Long
EC
CORP
US
N
1
N
N
Arcus Biosciences Inc
N/A
Arcus Biosciences Inc
03969F109
1003620.00000000
NS
USD
26053975.20000000
0.370051929402
Long
EC
CORP
US
N
1
N
N
Constellation Pharmaceuticals Inc
N/A
Constellation Pharmaceuticals Inc
210373106
1116393.00000000
NS
USD
32152118.40000000
0.456665570492
Long
EC
CORP
US
N
1
N
N
Arcutis Biotherapeutics Inc
N/A
Arcutis Biotherapeutics Inc
03969K108
517726.00000000
NS
USD
14563632.38000000
0.206851362218
Long
EC
CORP
US
N
1
N
N
Vir Biotechnology Inc
N/A
Vir Biotechnology Inc
92764N102
1986293.00000000
NS
USD
53192926.54000000
0.755514079735
Long
EC
CORP
US
N
1
N
N
Vericel Corp
54930076YM3PLTDR4B91
Vericel Corp
92346J108
1297884.00000000
NS
USD
40078657.92000000
0.569248438186
Long
EC
CORP
US
N
1
N
N
Viela Bio Inc
N/A
Viela Bio Inc
926613100
448826.00000000
NS
USD
16144271.22000000
0.229301619729
Long
EC
CORP
US
N
1
N
N
Radius Health Inc
549300EV6I2M6E0YVT27
Radius Health Inc
750469207
1457299.00000000
NS
USD
26027360.14000000
0.369673908227
Long
EC
CORP
US
N
1
N
N
ALX Oncology Holdings Inc
N/A
ALX Oncology Holdings Inc
00166B105
219027.00000000
NS
USD
18880127.40000000
0.268159753669
Long
EC
CORP
US
N
1
N
N
N
Emergent BioSolutions Inc
549300YW6TUOX8BE5103
Emergent BioSolutions Inc
29089Q105
762677.00000000
NS
USD
68335859.20000000
0.970593406580
Long
EC
CORP
US
N
1
N
N
Natera Inc
N/A
Natera Inc
632307104
661043.00000000
NS
USD
65786999.36000000
0.934391234192
Long
EC
CORP
US
N
1
N
N
N
Neurocrine Biosciences Inc
549300FECER0XBN49756
Neurocrine Biosciences Inc
64125C109
707477.00000000
NS
USD
67811670.45000000
0.963148206497
Long
EC
CORP
US
N
1
N
N
Exelixis Inc
N/A
Exelixis Inc
30161Q104
3211893.00000000
NS
USD
64462692.51000000
0.915581731949
Long
EC
CORP
US
N
1
N
N
Editas Medicine Inc
5299000AON4Q9NT2JE42
Editas Medicine Inc
28106W103
1030649.00000000
NS
USD
72258801.39000000
1.026312056621
Long
EC
CORP
US
N
1
N
N
Forma Therapeutics Holdings Inc
N/A
Forma Therapeutics Holdings Inc
34633R104
579414.00000000
NS
USD
20221548.60000000
0.287212335833
Long
EC
CORP
US
N
1
N
N
N
VBI Vaccines Inc
N/A
VBI Vaccines Inc
91822J103
19409028.00000000
NS
USD
53374827.00000000
0.758097663072
Long
EC
CORP
CA
N
1
N
N
Cytokinetics Inc
549300BE5DY1HW7IHA64
Cytokinetics Inc
23282W605
2719656.00000000
NS
USD
56514451.68000000
0.802690634452
Long
EC
CORP
US
N
1
N
N
Regeneron Pharmaceuticals Inc
549300RCBFWIRX3HYQ56
Regeneron Pharmaceuticals Inc
75886F107
133021.00000000
NS
USD
64263775.31000000
0.912756455074
Long
EC
CORP
US
N
1
N
N
N
Nurix Therapeutics Inc
N/A
Nurix Therapeutics Inc
67080M103
261383.00000000
NS
USD
8594273.04000000
0.122066874473
Long
EC
CORP
US
N
1
N
N
N
Syndax Pharmaceuticals Inc
529900OF94TRHKZVBS87
Syndax Pharmaceuticals Inc
87164F105
1220223.00000000
NS
USD
27137759.52000000
0.385445222579
Long
EC
CORP
US
N
1
N
N
OPKO Health Inc
529900A4S2D4OGOJLL02
OPKO Health Inc
68375N103
14341727.00000000
NS
USD
56649821.65000000
0.804613332167
Long
EC
CORP
US
N
1
N
N
REGENXBIO Inc
549300EOES47LATSET33
REGENXBIO Inc
75901B107
842683.00000000
NS
USD
38224100.88000000
0.542907643525
Long
EC
CORP
US
N
1
N
N
Immunovant Inc
N/A
Immunovant Inc
45258J102
1161578.00000000
NS
USD
53653287.82000000
0.762052720330
Long
EC
CORP
US
N
1
N
N
Biohaven Pharmaceutical Holding Co Ltd
5299007STZTNN32O9920
Biohaven Pharmaceutical Holding Co Ltd
000000000
731213.00000000
NS
USD
62672266.23000000
0.890151804490
Long
EC
CORP
VG
N
1
N
N
N
Arena Pharmaceuticals Inc
529900CVGQMPJ3A3NI85
Arena Pharmaceuticals Inc
040047607
922430.00000000
NS
USD
70870296.90000000
1.006590737261
Long
EC
CORP
US
N
1
N
N
Rocket Pharmaceuticals Inc
549300R7VV82YUIN4Y93
Rocket Pharmaceuticals Inc
77313F106
477208.00000000
NS
USD
26170086.72000000
0.371701093941
Long
EC
CORP
US
N
1
N
N
Atara Biotherapeutics Inc
549300WBXUXZRE03MS38
Atara Biotherapeutics Inc
046513107
1475679.00000000
NS
USD
28967578.77000000
0.411434659458
Long
EC
CORP
US
N
1
N
N
N
Coherus Biosciences Inc
5493007IL8W5MV932D26
Coherus Biosciences Inc
19249H103
2897641.00000000
NS
USD
50361000.58000000
0.715291439720
Long
EC
CORP
US
N
1
N
N
Neoleukin Therapeutics Inc
N/A
Neoleukin Therapeutics Inc
64049K104
639698.00000000
NS
USD
9019741.80000000
0.128109926803
Long
EC
CORP
US
N
1
N
N
Applied Molecular Transport Inc
N/A
Applied Molecular Transport Inc
03824M109
329810.00000000
NS
USD
10148253.70000000
0.144138498364
Long
EC
CORP
US
N
1
N
N
Alkermes PLC
N/A
Alkermes PLC
000000000
2996181.00000000
NS
USD
59773810.95000000
0.848984229852
Long
EC
CORP
IE
N
1
N
N
Alexion Pharmaceuticals Inc
M1YXUUZR0EIMU8T0EM75
Alexion Pharmaceuticals Inc
015351109
527546.00000000
NS
USD
82423787.04000000
1.170688203572
Long
EC
CORP
US
N
1
N
N
N
Amicus Therapeutics Inc
549300MRD1SMUTNBPQ53
Amicus Therapeutics Inc
03152W109
2887758.00000000
NS
USD
66678332.22000000
0.947051085215
Long
EC
CORP
US
N
1
N
N
N
Flexion Therapeutics Inc
549300X8HYW1HZKCDG90
Flexion Therapeutics Inc
33938J106
1670441.00000000
NS
USD
19276889.14000000
0.273795072129
Long
EC
CORP
US
N
1
N
N
Scholar Rock Holding Corp
549300Z1FLPGL4OWJ459
Scholar Rock Holding Corp
80706P103
231415.00000000
NS
USD
11230569.95000000
0.159510940130
Long
EC
CORP
US
N
1
N
N
N
PTC Therapeutics Inc
549300UJLWOIWFDGB318
PTC Therapeutics Inc
69366J200
982179.00000000
NS
USD
59942384.37000000
0.851378525496
Long
EC
CORP
US
N
1
N
N
Novavax Inc
529900J4GJHPEPQ23205
Novavax Inc
670002401
511095.00000000
NS
USD
56992203.45000000
0.809476277062
Long
EC
CORP
US
N
1
N
N
Karyopharm Therapeutics Inc
549300J1VANRCNTYST87
Karyopharm Therapeutics Inc
48576U106
4034744.00000000
NS
USD
62457837.12000000
0.887106207599
Long
EC
CORP
US
N
1
N
N
SpringWorks Therapeutics Inc
N/A
SpringWorks Therapeutics Inc
85205L107
632358.00000000
NS
USD
45858602.16000000
0.651342610052
Long
EC
CORP
US
N
1
N
N
uniQure NV
N/A
uniQure NV
000000000
999388.00000000
NS
USD
36107888.44000000
0.512850483709
Long
EC
CORP
NL
N
1
N
N
Xencor Inc
549300V5IF65437JKG30
Xencor Inc
98401F105
811620.00000000
NS
USD
35410980.60000000
0.502952105867
Long
EC
CORP
US
N
1
N
N
Allogene Therapeutics Inc
N/A
Allogene Therapeutics Inc
019770106
2327499.00000000
NS
USD
58746074.76000000
0.834387004012
Long
EC
CORP
US
N
1
N
N
Black Diamond Therapeutics Inc
N/A
Black Diamond Therapeutics Inc
09203E105
531362.00000000
NS
USD
17030152.10000000
0.241884034748
Long
EC
CORP
US
N
1
N
N
State Street Global Advisors
5493000HFJPORCLSV250
State Street Institutional Liquid Reserves Fund
85749P101
1207088.19000000
NS
USD
1207329.61000000
0.017148041639
Long
STIV
RF
US
N
1
N
N
N
Agenus Inc
529900NDQQGU5H4UJK81
Agenus Inc
00847G705
7469252.00000000
NS
USD
23752221.36000000
0.337359472955
Long
EC
CORP
US
N
1
N
N
Gilead Sciences Inc
549300WTZWR07K8MNV44
Gilead Sciences Inc
375558103
1050336.00000000
NS
USD
61192575.36000000
0.869135339357
Long
EC
CORP
US
N
1
N
N
N
MannKind Corp
213800GFBCNY1ZFST722
MannKind Corp
56400P706
5173452.00000000
NS
USD
16192904.76000000
0.229992375561
Long
EC
CORP
US
N
1
N
N
Zentalis Pharmaceuticals Inc
N/A
Zentalis Pharmaceuticals Inc
98943L107
421222.00000000
NS
USD
21878270.68000000
0.310743224977
Long
EC
CORP
US
N
1
N
N
CEL-SCI Corp
549300FIWOFSETIVMI17
CEL-SCI Corp
150837607
1363125.00000000
NS
USD
15894037.50000000
0.225747479903
Long
EC
CORP
US
N
1
N
N
2021-01-19
SPDR SERIES TRUST
Daniel Foley
Daniel Foley
Assistant Treasurer