UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, DC. 20549

SCHEDULE 14A

(Rule 14A-101)

INFORMATION REQUIRED IN PROXY STATEMENT

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of

the Securities Exchange Act of 1934

Filed by the Registrant x

Filed by a Party other than the Registrant

Check the appropriate box:

o	Preliminary Proxy Statement	o	Confidential, for Use of the Commission Only
o	Definitive Proxy Statement		(as permitted by Rule 14a-6(e)(2))
x	Definitive Additional Materials
o	Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12

 LEXICON PHARMACEUTICALS, INC.

 (Name of Registrant as Specified In Its Charter)

 (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

Payment of Filing Fee (Check the appropriate box):

 x No fee required.

o Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

(1)	Title of each class of securities to which transaction applies:  N/A
(2)	Aggregate number of securities to which transaction applies:  N/A
(3)	Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined):  N/A
(4)	Proposed maximum aggregate value of transaction:  N/A
(5)	Total fee paid:  $0

 o Fee paid previously with preliminary materials:  N/A

 o Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing.

(1)	Amount Previously Paid:
(2)	Form, Schedule or Registration Statement No.:
(3)	Filing Party:
(4)	Date Filed

Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting to be held on 4/23/08

This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting.

The following materials are available for view:

Notice and Proxy Statement / Annual Report

To view this material, have the 12-digit Control #(s) available and visit: www.proxyvote.com

If you want to receive a paper or e-mail copy of the above listed documents you must request one. There is no charge to you for requesting a copy.

To facilitate timely delivery please make the request as instructed below on or before 4/9/08.

To request material: Internet:  www.proxyvote.com Telephone: 1-800-579-1639 **Email:  sendmaterial@proxyvote.com

**If requesting material by e-mail please send a blank e-mail with the 12-digit Control# (located on the following page) in the subject line. Requests, instructions and other inquiries will NOT be forwarded to your investment advisor.

		LEXICON PHARMACEUTICALS, INC.
		Vote In Person
LEXICON PHARMACEUTICALS, INC. 8800  TECHNOLOGY  FOREST  PLACE THE  WOODLANDS,  TX  77381-4287		Many  stockholder  meetings  have  attendance  requirements including,  but  not  limited  to,  the  possession  of  an  attendance ticket issued by the entity holding the meeting. Please check the meeting  materials  for  any  special  requirements  for  meeting attendance. At the Meeting you will need to request a ballot to vote these  shares.
		Vote By Internet
		To vote now by Internet, go to WWW.PROXYVOTE.COM. Use the Internet to transmit your voting instructions and for electronic delivery of information up until 11:59 P.M. Eastern Time the day before the cut-off date or meeting date. Have your notice in hand when you access the web site and follow the instructions.

Meeting  Location

The Annual Meeting for holders as of 2/26/08 is to be held on 4/23/08 at 1:30 p.m. Central at:

The Woodlands Waterway Marriot Hotel and Convention Center

1601 Lake Robbins Drive

The Woodlands, TX 77380

For meeting directions, please call: 281-863-3503

  Voting  items 

THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR”  ITEMS 1 AND 2.

1. ELECTION OF CLASS II DIRECTORS

Nominees:

01) Samuel L. Barker, Ph.D.

02) Christopher J. Sobecki

03) Judith L. Swain, M.D.

04) Kathleen M. Wiltsey

2.           Ratification and approval of the appointment of Ernst & Young LLP as the Company's independent auditors for the fiscal year ending December 31, 2008.

3.           In their discretion, upon such other matters that may properly come before the meeting or any adjournment or adjournments thereof.