Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenues:
Net product revenue	$ 0	$ 0	$ 23,404,000
Collaborative agreements	0	0	33,000
Royalties and other revenue	139,000	298,000	558,000
Total revenues	139,000	298,000	23,995,000
Operating expenses:
Cost of sales (including finite-lived intangible asset amortization)	0	0	1,929,000
Research and development, including stock-based compensation of $4,253, $4,284 and $6,376 respectively	52,816,000	55,046,000	153,621,000
Selling, general and administrative, including stock-based compensation of $7,267, $6,293 and $6,898, respectively	48,083,000	32,342,000	47,230,000
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)	0	0	1,600,000
Total operating expenses	100,899,000	87,388,000	204,380,000
Gain on sale of non-financial assets	0	0	132,585,000
Income (loss) from operations	(100,760,000)	(87,090,000)	(47,800,000)
Recognition of gain or loss on extinguishment	0	0	1,003,000
Interest expense	(2,780,000)	(802,000)	(14,544,000)
Interest and other income, net	1,596,000	134,000	2,767,000
Income tax benefit	0	0	0
Net loss	(101,944,000)	(87,758,000)	(58,574,000)
Other comprehensive loss:
Unrealized gain (loss) on investments	(418,000)	(4,000)	(90,000)
Comprehensive loss	$ (102,362,000)	$ (87,762,000)	$ (58,664,000)
Earnings Per Share, Basic	$ (0.62)	$ (0.60)	$ (0.53)
Weighted Average Number of Shares Issued, Basic	165,733	145,652	110,841