Summary of Significant Accounting Policies Accrued Liabilities (Details) - USD ($)	Mar. 31, 2022	Dec. 31, 2021	Mar. 01, 2021
Accrued Liabilities [Line Items]
Accrued research and development services current	$ 5,308,000	$ 3,669,000
Accrued compensation and benefits current	2,616,000	5,711,000
Operating Lease, Liability, Current	(940,000)	(1,089,000)
Other Accrued Liabilities, Current	720,000	2,503,000
Accrued Liabilities	$ 9,584,000	$ 12,972,000
Lexicon incremental borrowing rate			900.00%