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Other Capital Agreements	3 Months Ended
Other Capital Agreements	Mar. 31, 2022
Equity [Abstract]
Other Capital Agreements	Other Capital Agreements Common Stock: In 2020, Lexicon entered into an Open Market Sale AgreementSM (the “Sales Agreement”) with Jefferies LLC (“Jefferies”) relating to the shares of its common stock. In January 2021, Lexicon sold 2,000,000 shares of its common stock at a price of $8.463 per share pursuant to the Sales Agreement, resulting in net proceeds of $16.4 million. The net proceeds are reflected as issuances of common stock in the accompanying condensed consolidated financial statements. In August and September 2021, Lexicon sold an aggregate of 4,176,953 shares of its common stock at a price of $4.732 per share pursuant to the Sales Agreement, resulting in net proceeds of $19.1 million.