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Consolidated Statements of Stockholders' Equity - USD ($)
Total
Common Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Other Comprehensive Gain (Loss)
Treasury Stock
Balance, shares at Dec. 31, 2018   106,162,000        
Balance, value at Dec. 31, 2018 $ (26,405,000) $ 106,000 $ 1,447,954,000 $ (1,471,577,000) $ (12,000) $ (2,876,000)
Stock-based compensation 14,218,000 $ 0 14,218,000 0 0 0
Issuance of common stock under Equity Incentive Plans, shares   517,000        
Issuance of common stock under Equity Incentive Plans, value 0 $ 0 0 0 0 0
Repurchase of common stock (941,000) 0 0 0 0 (941,000)
Net loss 130,133,000 0 0 130,133,000 0 0
Unrealized gain (loss) on investments 96,000 $ 0 0 0 96,000 0
Balance, shares at Dec. 31, 2019   106,679,000        
Balance, value at Dec. 31, 2019 117,101,000 $ 106,000 1,462,172,000 (1,341,444,000) 84,000 (3,817,000)
Stock-based compensation 13,274,000 0 13,274,000 0 0 0
Stock Issued During Period, Value, New Issues 6,963,000 $ 4,000 6,959,000 0 0 0
Stock Issued During Period, Shares, New Issues   3,709,000        
Sale of Stock, Consideration Received Per Transaction 63,007,000 $ 20,000 62,987,000 0 0 0
Common stock, shares issued   10,369,000        
Issuance of common stock under Equity Incentive Plans, shares   1,219,000        
Issuance of common stock under Equity Incentive Plans, value 2,000 $ 2,000 0 0 0 0
Repurchase of common stock (1,026,000) 0 0 0 0 (1,026,000)
Net loss (58,574,000) 0 0 (58,574,000) 0 0
Unrealized gain (loss) on investments (90,000) $ 0 0 0 (90,000) 0
Balance, shares at Dec. 31, 2020   142,289,000        
Balance, value at Dec. 31, 2020 $ 156,371,000 $ 142,000 1,561,096,000 (1,400,018,000) (6,000) (4,843,000)
Sale of Stock, Number of Shares Issued in Transaction 20,312,500 20,313,000        
Conversion of Stock, Amount Issued $ 15,714,000 $ 10,000 15,704,000 0 0 0
Proceeds from Nov 2020 ATM Offering 7,000,000          
Commissions from December 2020 Common Stock Offering 1,800,000          
Offering expenses from December 20 common stock offering 200,000          
ATM Offering Total $ 50,000,000          
Shares Issued, Price Per Share $ 3.200          
Proceeds from December 2020 common stock offering $ 63,000,000          
Stock-based compensation 10,577,000 0 10,577,000 0 0 0
Stock Issued During Period, Value, New Issues 35,491,000 $ 6,000 35,485,000 0 0 0
Stock Issued During Period, Shares, New Issues   6,177,000        
Issuance of common stock under Equity Incentive Plans, shares   1,616,000        
Issuance of common stock under Equity Incentive Plans, value 1,593,000 $ 2,000 1,591,000 0 0 0
Repurchase of common stock (2,675,000) 0 0 0 0 (2,675,000)
Net loss (87,758,000) 0 0 (87,758,000) 0 0
Unrealized gain (loss) on investments (4,000) $ 0 0 0 (4,000) 0
Balance, shares at Dec. 31, 2021   150,082,000        
Balance, value at Dec. 31, 2021 113,595,000 $ 150,000 $ 1,608,749,000 $ (1,487,776,000) $ (10,000) $ (7,518,000)
Share price in November 20 ATM Offering $ 1.992          
Other Capital Agreements Other Capital Agreements
 
Common Stock: In December 2020, Lexicon sold 20,312,500 shares of its common stock at a price of $3.200 per share in a registered direct offering pursuant to an existing shelf registration statement. Sale of the shares resulted in net proceeds of $63.0 million, after deducting underwriting discounts and commissions of $1.8 million and offering expenses of $0.2 million. The investors in the offering were Artal International S.C.A., an affiliate of of Invus, L.P., the Company’s largest stockholder, and BVF Partners L.P. and certain affiliates of BVF Partners L.P. All of the net proceeds of the registered direct offering are reflected as issuance of common stock in the accompanying financial statements.

In October 2020, Lexicon entered into an Open Market Sale AgreementSM (the “sales agreement”) with Jefferies LLC (“Jefferies”) relating to the shares of its common stock. Lexicon may offer and sell common stock having an aggregate sales price of up to $50,000,000 from time to time through Jefferies acting as its sales agent. In November 2020, Lexicon sold 3,709,233 shares of its common stock at a price of $1.992 per share pursuant to the sales agreement, resulting in net proceeds of $7.0 million. In January 2021, Lexicon sold 2,000,000 shares of its common stock at a price of $8.463 per share pursuant to the sales agreement, resulting in net proceeds of $16.4 million. In August and September 2021, Lexicon sold an aggregate of 4,176,953 shares of its common stock at a price of $4.732 per share pursuant to the sales agreement, resulting in net proceeds of $19.1 million. The net proceeds from each of these sales are reflected as issuances of common stock in the accompanying financial statements.