Income Taxes (Details 1) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Deferred Tax Assets and Liabilities
Deferred Tax Assets, Operating Loss Carryforwards	$ 229,427	$ 201,610
Deferred Tax Assets, Tax Credit Carryforwards, Research	29,290	29,304
Deferred Tax Assets, Tax Credit Carryforwards, Orphan Drug	24,524	24,524
Deferred Tax Assets, In Process Research and Development	36,770	47,075
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost	5,163	5,651
Deferred Tax Assets, Other	1,308	844
Deferred Tax Assets, Gross	326,630	309,008
Deferred Tax Liabilities, Other	(412)	0
Deferred Tax Liabilities, Gross	(412)	0
Deferred Tax Assets, Valuation Allowance	(326,218)	(309,008)
Deferred Tax Liabilities, Net	0	0
Income Tax Benefit	0	0	$ (6,014)
2020 Federal NOL increase	132,700
Deferred Tax Assets, Section 163j_LXRX	148	$ 0
Operating Loss Carryforwards, Federal	1,100,000
Deferred Tax Assets, Operating Loss Carryforwards, Domestic	$ 342,000