Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues:
Net product revenue	$ 0	$ 23,404,000	$ 32,331,000
Collaborative agreements	0	33,000	289,231,000
Royalties and other revenue	298,000	558,000	511,000
Total revenues	298,000	23,995,000	322,073,000
Operating expenses:
Cost of sales (including finite-lived intangible asset amortization)	0	1,929,000	3,231,000
Research and development, including stock-based compensation of $4,284, $6,376 and $7,096 respectively	55,046,000	153,621,000	91,924,000
Selling, general and administrative, including stock-based compensation of $6,293, $6,898 and $7,122, respectively	32,342,000	47,230,000	56,835,000
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)	0	1,600,000	0
Goodwill and Intangible Asset Impairment	0	0	28,638,000
Total operating expenses	87,388,000	204,380,000	180,628,000
Gain on sale of non-financial assets	0	132,585,000	0
Income (loss) from operations	(87,090,000)	(47,800,000)	141,445,000
Recognition of gain or loss on extinguishment	0	1,003,000	0
Interest expense	(802,000)	(14,544,000)	(20,676,000)
Interest and other income, net	134,000	2,767,000	3,350,000
Net income (loss) before taxes	(87,758,000)	(58,574,000)	124,119,000
Income tax benefit	0	0	6,014,000
Net income (loss)	(87,758,000)	(58,574,000)	130,133,000
Other comprehensive loss:
Unrealized gain (loss) on investments	(4,000)	(90,000)	96,000
Comprehensive loss	$ (87,762,000)	$ (58,664,000)	$ 130,229,000
Earnings Per Share, Basic	$ (0.60)	$ (0.53)	$ 1.23
Earnings Per Share, Diluted	$ (0.60)	$ (0.53)	$ 1.16
Weighted Average Number of Shares Outstanding, Diluted	145,652	110,841	116,747
Weighted Average Number of Shares Issued, Basic	145,652	110,841	106,218