Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Revenues:
Net product revenue	$ 23,404,000	$ 32,331,000	$ 26,583,000
Collaborative agreements	33,000	289,231,000	36,271,000
Royalties and other revenue	558,000	511,000	355,000
Total revenues	23,995,000	322,073,000	63,209,000
Operating expenses:
Cost of sales (including finite-lived intangible asset amortization)	1,929,000	3,231,000	2,491,000
Research and development, including stock-based compensation of $6,376, $7,096 and $6,010 respectively	153,621,000	91,924,000	100,243,000
Selling, general and administrative, including stock-based compensation of $6,898, $7,122 and $5,686, respectively	47,230,000	56,835,000	63,754,000
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)	1,600,000	0	0
Goodwill and Intangible Asset Impairment		28,638,000
Total operating expenses	204,380,000	180,628,000	166,488,000
Gain on sale of non-financial assets	132,585,000	0	0
Income (loss) from operations	(47,800,000)	141,445,000	(103,279,000)
Recognition of gain or loss on extinguishment	1,003,000	0	0
Interest expense	(14,544,000)	(20,676,000)	(20,777,000)
Interest and other income, net	2,767,000	3,350,000	3,508,000
Net income (loss) before taxes	(58,574,000)	124,119,000	(120,548,000)
Income tax benefit	0	6,014,000	0
Net income (loss)	(58,574,000)	130,133,000	(120,548,000)
Other comprehensive loss:
Unrealized gain (loss) on investments	(90,000)	96,000	210,000
Comprehensive loss	$ (58,664,000)	$ 130,229,000	$ (120,338,000)
Earnings Per Share, Basic	$ (0.53)	$ 1.23	$ (1.14)
Earnings Per Share, Diluted	$ (0.53)	$ 1.16	$ (1.14)
Weighted Average Number of Shares Outstanding, Diluted	110,841	116,747	105,830
Weighted Average Number of Shares Issued, Basic	110,841	106,218	105,830