Summary of Significant Accounting Policies Equity Incentive Awards (Tables)

3 Months Ended

9 Months Ended

Sep. 30, 2020

Sep. 30, 2020

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Abstract]

Schedule of Accrued Liabilities

Accrued liabilities: Accrued liabilities consisted of the following:

	As of September 30,		As of December 31,
	2020		2019
	(in thousands)
Accrued research and development services	$	50,217	$	29,033
Accrued compensation and benefits	6,023		9,644
Short term lease liability	553		553
Other	1,704		2,921
Accrued liabilities	$	58,497	$	42,151

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

	Expected Volatility		Risk-free Interest Rate		Expected Term	Dividend Rate
September 30, 2020:
Employees	91	%	1.3	%	4	—	%
Officers and non-employee directors	78	%	1.4	%	8	—	%
September 30, 2019:
Employees	88	%	2.2	%	4	—	%
Officers and non-employee directors	78	%	2.6	%	8	—	%

Share-based Payment Arrangement, Option, Activity [Table Text Block]

	Options	Weighted Average Exercise Price
	(in thousands)
Outstanding at December 31, 2019	7,695	$	8.95
Granted	3,445	3.25
Expired	(236)	12.91
Forfeited (1)	(1,909)	5.71
Outstanding at September 30, 2020	8,995	7.35
Exercisable at September 30, 2020	5,108	$	9.63

Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]

	Shares	Weighted Average Grant Date Fair Value
	(in thousands)
Outstanding at December 31, 2019	2,830	$	6.35
Granted	3,144	3.27
Vested	(1,219)	6.56
Forfeited (1)	(1,892)	4.13
Outstanding at September 30, 2020	2,863	$	4.35