Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Revenues:
Net product revenue	$ 32,331	$ 26,583	$ 15,890
Collaborative agreements	289,231	36,271	75,621
Royalties and other revenue	511	355	178
Total revenues	322,073	63,209	91,689
Operating expenses:
Cost of sales (including finite-lived intangible asset amortization)	3,231	2,491	1,899
Research and development, including stock-based compensation of $7,096, $6,010, and $4,905, respectively	91,924	100,243	152,223
Increase in fair value of Symphony Icon, Inc. purchase liability	0	0	2,101
General and administrative, including stock-based compensation of $7,122, $5,686, and $4,567, respectively	56,835	63,754	66,090
Total operating expenses	180,628	166,488	222,313
Income (loss) from operations	141,445	(103,279)	(130,624)
Interest expense	(20,676)	(20,777)	(6,984)
Interest and other income, net	3,350	3,508	1,954
Net income (loss) before taxes	124,119	(120,548)	(135,654)
Income tax benefit	6,014	0	12,661
Net income (loss)	130,133	(120,548)	(122,993)
Other comprehensive loss:
Unrealized gain (loss) on investments	96	210	(27)
Comprehensive loss	$ 130,229	$ (120,338)	$ (123,020)
Earnings Per Share, Basic	$ 1.23	$ (1.14)	$ (1.17)
Earnings Per Share, Diluted	$ 1.16	$ (1.14)	$ (1.17)
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)	$ 28,638	$ 0	$ 0
Weighted Average Number of Shares Outstanding, Diluted	116,747	105,830	105,237
Weighted Average Number of Shares Issued, Basic	106,218	105,830	105,237