Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Revenues:
Net product revenue	$ 8,672	$ 7,316	$ 15,412	$ 12,776
Revenue from Contract with Customer, Excluding Assessed Tax	860	6,404	3,299	26,236
Royalties and other revenue	150	78	187	160
Total revenues	9,682	13,798	18,898	39,172
Operating expenses:
Cost of sales (including finite-lived intangible asset amortization)	1,327	838	1,880	1,371
Research and development, including stock-based compensation of $1,903, $1,395, $3,671 and $3,050, respectively	12,637	26,477	24,659	74,173
Selling, general and administrative expenses, included stock-based compensation of $1,863, $1,503, $3,506 and $2,922, respectively	14,263	16,755	28,373	31,612
Total operating expenses	28,227	44,070	54,912	107,156
Loss from operations	(18,545)	(30,272)	(36,014)	(67,984)
Interest expense	(5,164)	(5,187)	(10,281)	(10,300)
Interest and other income, net	691	910	1,480	1,915
Net loss	$ (23,018)	$ (34,549)	$ (44,815)	$ (76,369)
Net loss per common share, basic and diluted	$ (0.22)	$ (0.33)	$ (0.42)	$ (0.72)
Shares used in computing net loss per common share, basic and diluted	106,272	105,848	106,164	105,758
Unrealized gain on investments	$ 53	$ 176	$ 98	$ 4
Comprehensive loss	$ (22,965)	$ (34,373)	$ (44,717)	$ (76,365)