Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Revenues:
Net product revenue	$ 6,740	$ 5,460
Revenue from Contract with Customer, Excluding Assessed Tax	2,439	19,832
Royalties and other revenue	37	82
Total revenues	9,216	25,374
Operating expenses:
Cost of sales (including finite-lived intangible asset amortization)	553	533
Research and development, including stock-based compensation of $1,768 and $1,655, respectively	12,022	47,696
Selling, general and administrative expenses, included stock-based compensation of $1,643 and $1,419, respectively	14,110	14,857
Total operating expenses	26,685	63,086
Loss from operations	(17,469)	(37,712)
Interest expense	(5,117)	(5,113)
Interest and other income, net	789	1,005
Net loss	$ (21,797)	$ (41,820)
Net loss per common share, basic and diluted	$ (0.21)	$ (0.40)
Shares used in computing net loss per common share, basic and diluted	106,054	105,668
Unrealized gain on investments	$ 45	$ (172)
Comprehensive loss	$ (21,752)	$ (41,992)