Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues:
Net product revenue	$ 6,286	$ 5,830	$ 19,062	$ 10,443
Collaborative agreements	446	21,112	26,470	46,781
Royalties and other revenue	124	0	284	64
Total revenues	6,856	26,942	45,816	57,288
Operating expenses:
Cost of sales (including finite-lived intangible asset amortization)	551	599	1,922	1,361
Research and development, including stock-based compensation of $1,472, $1,345, $4,522 and $3,698, respectively	13,769	39,137	88,141	109,653
Increase in fair value of Symphony Icon, Inc. purchase liability	0	0	0	2,101
Selling, general and administrative expenses, included stock-based compensation of $1,405, $1,235, $4,327 and $3,516, respectively	15,579	16,724	47,191	50,069
Total operating expenses	29,899	56,460	137,254	163,184
Loss from operations	(23,043)	(29,518)	(91,438)	(105,896)
Interest expense	(5,252)	(1,619)	(15,553)	(4,821)
Interest and other income, net	783	415	2,698	1,393
Net loss before taxes	(27,512)	(30,722)	(104,293)	(109,324)
Income Tax Benefit	0	0	0	(8,652)
Net loss	$ (27,512)	$ (30,722)	$ (104,293)	$ (100,672)
Net loss per common share, basic and diluted	$ (0.26)	$ (0.29)	$ (0.99)	$ (0.96)
Shares used in computing net loss per common share, basic and diluted	105,881	105,582	105,800	105,119
Unrealized gain on investments	$ 147	$ 151	$ 151	$ 132
Comprehensive loss	$ (27,365)	$ (30,571)	$ (104,142)	$ (100,540)