Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenues:
Net product revenue	$ 7,316	$ 3,892	$ 12,776	$ 4,613
Collaborative agreements	6,359	8,104	26,024	25,669
Royalties and other revenue	78	57	160	64
Total revenues	13,753	12,053	38,960	30,346
Operating expenses:
Cost of sales (including finite-lived intangible asset amortization)	838	537	1,371	762
Research and development, including stock-based compensation of $1,395, $1,169, $3,050 and $2,353, respectively	26,589	26,934	74,372	70,515
Increase in fair value of Symphony Icon, Inc. purchase liability	0	0	0	2,101
Selling, general and administrative expenses, included stock-based compensation of $1,503, $1,234, $2,922 and $2,281, respectively	16,755	18,475	31,612	33,346
Total operating expenses	44,182	45,946	107,355	106,724
Loss from operations	(30,429)	(33,893)	(68,395)	(76,378)
Interest expense	(5,187)	(1,614)	(10,301)	(3,202)
Interest and other income, net	910	448	1,915	978
Net loss before taxes	(34,706)	(35,059)	(76,781)	(78,602)
Income Tax Benefit	0	0	0	(8,652)
Net loss	$ (34,706)	$ (35,059)	$ (76,781)	$ (69,950)
Net loss per common share, basic and diluted	$ (0.33)	$ (0.33)	$ (0.73)	$ (0.67)
Shares used in computing net loss per common share, basic and diluted	105,848	105,300	105,758	104,883
Unrealized gain (loss) on investments	$ 175	$ 50	$ 4	$ (19)
Comprehensive loss	$ (34,531)	$ (35,009)	$ (76,777)	$ (69,969)