Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Revenues:
Net product revenue	$ 5,460	$ 721
Collaborative agreements	19,665	17,565
Royalties and other revenue	82	7
Total revenues	25,207	18,293
Operating expenses:
Cost of sales (including finite-lived intangible asset amortization)	533	225
Research and development, including stock-based compensation of $1,655 and $1,184, respectively	47,783	43,581
Increase in fair value of Symphony Icon, Inc. purchase liability	0	2,101
Selling, general and administrative, including stock-based compensation of $1,419 and $1,047, respectively	14,857	14,871
Total operating expenses	63,173	60,778
Loss from operations	(37,966)	(42,485)
Interest expense	(5,114)	(1,588)
Interest and other income, net	1,005	530
Net loss before taxes	(42,075)	(43,543)
Income tax benefit	0	(8,652)
Net loss	$ (42,075)	$ (34,891)
Net loss per common share, basic and diluted	$ (0.40)	$ (0.33)
Shares used in computing consolidated net loss per common share, basic and diluted	105,668	104,461
Unrealized loss on investments	$ (172)	$ (69)
Comprehensive loss	$ (42,247)	$ (34,960)