Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenues:
Net product revenue	$ 15,890,000	$ 0	$ 0
Collaborative agreements	74,267,000	83,182,000	129,728,000
Royalties and other revenue	178,000	155,000	286,000
Total revenues	90,335,000	83,337,000	130,014,000
Operating expenses:
Cost of Goods Sold	1,899,000	0	0
Research and development, including stock-based compensation of $4,905, $3,938 and $3,693, respectively	156,813,000	178,151,000	95,187,000
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability	2,101,000	(703,000)	5,927,000
General and administrative, including stock-based compensation of $4,567, $3,514 and $3,150, respectively	66,203,000	43,044,000	23,835,000
Impairment loss on buildings	0	0	3,597,000
Total operating expenses	227,016,000	220,492,000	128,546,000
Income (loss) from operations	(136,681,000)	(137,155,000)	1,468,000
Interest expense	(6,984,000)	(6,567,000)	(6,722,000)
Interest and other income, net	1,954,000	2,293,000	572,000
Consolidated net loss before taxes	(141,711,000)	(141,429,000)	(4,682,000)
Deferred Income Tax Expense (Benefit)	(12,661,000)	0	0
Income tax benefit		0	0
Consolidated net loss	$ (129,050,000)	$ (141,429,000)	$ (4,682,000)
Consolidated net loss per common share, basic and diluted	$ (1.23)	$ (1.36)	$ (0.05)
Shares used in computing consolidated net loss per common share, basic and diluted	105,237	103,863	103,591
Other comprehensive loss:
Unrealized gain (loss) on investments	$ (27,000)	$ 24,000	$ (156,000)
Comprehensive loss	$ (129,077,000)	$ (141,405,000)	$ (4,838,000)