Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenues:
Net product revenue	$ 5,830	$ 0	$ 10,443	$ 0
Collaborative agreements	21,112	27,686	46,781	60,181
Subscription and license fees	0	31	64	119
Total revenues	26,942	27,717	57,288	60,300
Operating expenses:
Cost of sales (including finite-lived intangible asset amortization)	599	0	1,361	0
Research and development, including stock-based compensation of $1,345, $1,051, $3,698 and $3,013, respectively	39,137	52,533	109,653	137,751
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability	0	(2,146)	2,101	(703)
Selling, general and administrative, including stock-based compensation of $1,235, $879, $3,516 and $2,709, respectively	16,724	12,263	50,069	29,077
Total operating expenses	56,460	62,650	163,184	166,125
Loss from operations	(29,518)	(34,933)	(105,896)	(105,825)
Interest expense	(1,619)	(1,646)	(4,821)	(4,933)
Interest and other income, net	415	564	1,393	1,748
Net loss before taxes	(30,722)	(36,015)	(109,324)	(109,010)
Income tax benefit	0	0	(8,652)	0
Net loss	$ (30,722)	$ (36,015)	$ (100,672)	$ (109,010)
Net loss per common share, basic and diluted	$ (0.29)	$ (0.35)	$ (0.96)	$ (1.05)
Shares used in computing consolidated net loss per common share, basic and diluted	105,582	103,885	105,119	103,799
Unrealized gain (loss) on investments	$ 151	$ (258)	$ 132	$ 297
Comprehensive loss	$ (30,571)	$ (36,273)	$ (100,540)	$ (108,713)