Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Revenues:
Net product revenue	$ 3,892	$ 0	$ 4,613	$ 0
Collaborative agreements	8,104	20,001	25,669	32,495
Subscription and license fees	57	88	64	88
Total revenues	12,053	20,089	30,346	32,583
Operating expenses:
Cost of sales (including finite-lived intangible asset amortization)	537	0	762	0
Research and development, including stock-based compensation of $1,169, $973, $2,353 and $1,962, respectively	26,934	48,216	70,515	85,218
Increase in fair value of Symphony Icon, Inc. purchase liability	0	478	2,101	1,443
Selling, general and administrative, including stock-based compensation of $1,234, $984, $2,281 and $1,830, respectively	18,475	8,416	33,346	16,814
Total operating expenses	45,946	57,110	106,724	103,475
Loss from operations	(33,893)	(37,021)	(76,378)	(70,892)
Interest expense	(1,614)	(1,638)	(3,202)	(3,287)
Interest and other income, net	448	547	978	1,184
Consolidated net loss before taxes	(35,059)	(38,112)	(78,602)	(72,995)
Deferred tax benefit	0	0	(8,652)	0
Net loss	$ (35,059)	$ (38,112)	$ (69,950)	$ (72,995)
Net loss per common share, basic and diluted	$ (0.33)	$ (0.37)	$ (0.67)	$ (0.70)
Shares used in computing consolidated net loss per common share, basic and diluted	105,300	103,830	104,883	103,756
Unrealized gain (loss) on investments	$ 50	$ 39	$ (19)	$ 555
Comprehensive loss	$ (35,009)	$ (38,073)	$ (69,969)	$ (72,440)