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Cash and Cash Equivalents and Investments (Details 1) - USD ($)
$ in Thousands
Jun. 30, 2017
Dec. 31, 2016
Cash and Cash Equivalents    
Fair Value    
Amortized Cost $ 30,706 $ 46,600
Gross Unrealized Gains 0 0
Gross Unrealized Losses 0 0
Estimated Fair Value 30,706 46,600
U.S. Treasury Securities    
Fair Value    
Amortized Cost 161,020 227,911
Gross Unrealized Gains 0 1
Gross Unrealized Losses (178) (107)
Estimated Fair Value 160,842 227,805
Corporate Debt Securities    
Fair Value    
Amortized Cost 39,675 72,188
Gross Unrealized Gains 0 1
Gross Unrealized Losses (36) (90)
Estimated Fair Value 39,639 72,099
Total Short-term Investments    
Fair Value    
Amortized Cost 200,695 300,099
Gross Unrealized Gains 0 2
Gross Unrealized Losses (214) (197)
Estimated Fair Value 200,481 299,904
Total Cash and Cash Equivalents and Investments    
Fair Value    
Amortized Cost 231,401 346,699
Gross Unrealized Gains 0 2
Gross Unrealized Losses (214) (197)
Estimated Fair Value $ 231,187 $ 346,504