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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Cash flows from operating activities:    
Net loss $ (34,891) $ (34,883)
Adjustments to reconcile consolidated net loss to net cash used in operating activities:    
Depreciation and amortization 634 521
Increase in fair value of Symphony Icon, Inc. purchase liability 2,101 965
Stock-based compensation 2,231 1,835
Amortization of debt issuance costs 110 125
Deferred tax benefit (8,652) 0
Loss on disposal of property and equipment 0 12
Changes in operating assets and liabilities:    
(Increase) decrease in accounts receivable (1,241) 170
Increase in inventory (236) 0
Increase in prepaid expenses and other current assets (6,498) (4,134)
Decrease in other assets 33 0
Increase (decrease) in accounts payable and other liabilities (24,703) 3,836
Decrease in deferred revenue (14,384) (12,187)
Net cash used in operating activities (85,496) (43,740)
Cash flows from investing activities:    
Purchases of property and equipment (92) (54)
Purchases of investments (60,905) (208,986)
Maturities of investments 103,452 75,400
Net cash provided by (used in) investing activities 42,455 (133,640)
Cash flows from financing activities:    
Proceeds from issuance of common stock 1,111 184
Repurchase of common stock (1,679) (621)
Repayment of debt borrowings (536) (491)
Net cash used in financing activities (1,104) (928)
Net decrease in cash and cash equivalents (44,145) (178,308)
Cash and cash equivalents at beginning of period 46,600 202,989
Cash and cash equivalents at end of period 2,455 24,681
Supplemental disclosure of cash flow information:    
Cash paid for interest 332 378
Supplemental disclosure of non-cash investing and financing activities:    
Common stock issued in satisfaction of Symphony Icon payment obligation 10,499 0
Unrealized gain (loss) on investments $ (69) $ 516