Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Revenues:
Net product revenue	$ 721	$ 0
Collaborative agreements	17,565	12,494
Subscription and license fees	7	0
Total revenues	18,293	12,494
Operating expenses:
Cost of sales (including finite-lived intangible asset amortization)	225	0
Research and development, including stock-based compensation of $1,184 and $989, respectively	43,581	37,002
Increase in fair value of Symphony Icon, Inc. purchase liability	2,101	965
Selling, general and administrative, including stock-based compensation of $1,047 and $846, respectively	14,871	8,398
Total operating expenses	60,778	46,365
Loss from operations	(42,485)	(33,871)
Interest expense	(1,588)	(1,649)
Interest and other income, net	530	637
Consolidated net loss before taxes	(43,543)	(34,883)
Deferred tax benefit	(8,652)	0
Net loss	$ (34,891)	$ (34,883)
Net loss per common share, basic and diluted	$ (0.33)	$ (0.34)
Shares used in computing consolidated net loss per common share, basic and diluted	104,461	103,682
Unrealized gain (loss) on investments	$ (69)	$ 516
Comprehensive loss	$ (34,960)	$ (34,367)