Income Taxes (Details 1) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Deferred Tax Assets and Liabilities
Deferred Tax Assets, Operating Loss Carryforwards	$ 258,405	$ 263,138
Deferred Tax Assets, Tax Credit Carryforwards, Research	44,111	43,728
Deferred Tax Assets, Tax Credit Carryforwards, Orphan Drug	24,233	0
Deferred Tax Assets, In Process Research and Development	86,845	85,385
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost	7,060	8,160
Deferred Tax Assets, Deferred Income	39,307	4,363
Deferred Tax Assets, Other	8,432	8,831
Deferred Tax Assets, Gross	468,393	413,605
Deferred Tax Liability Related to Acquisition of Symphony Icon	(18,675)	(18,675)
Deferred Tax Liabilities, Gross	(18,675)	(18,675)
Deferred Tax Assets, Valuation Allowance	(468,393)	(413,605)
Deferred Tax Liabilities, Net	$ (18,675)	$ (18,675)