Property and Equipment (Details 1) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Property, Plant and Equipment
Property, Plant and Equipment, Gross	$ 79,265	$ 80,655
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment	(59,875)	(59,428)
Property, Plant and Equipment, Net	19,390	21,227
Computers and Software
Property, Plant and Equipment
Property, Plant and Equipment, Gross	7,667	8,457
Furniture and Fixtures
Property, Plant and Equipment
Property, Plant and Equipment, Gross	6,003	6,269
Laboratory Equipment
Property, Plant and Equipment
Property, Plant and Equipment, Gross	3,423	3,908
Leasehold Improvements
Property, Plant and Equipment
Property, Plant and Equipment, Gross	296	240
Buildings
Property, Plant and Equipment
Property, Plant and Equipment, Gross	59,212	59,117
Land
Property, Plant and Equipment
Property, Plant and Equipment, Gross	$ 2,664	$ 2,664