Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Revenues:
Collaborative agreements	$ 27,686	$ 505	$ 60,181	$ 2,635
Subscription and license fees	31	61	119	99
Total revenues	27,717	566	60,300	2,734
Operating expenses:
Research and development, including stock-based compensation of $1,051, $893, $3,013 and $2,865, respectively	52,533	23,111	137,751	64,745
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability	(2,146)	3,404	(703)	5,145
General and administrative, including stock-based compensation of $879, $779, $2,709 and $2,548, respectively	12,263	5,379	29,077	17,387
Impairment loss on buildings	0	2,349	0	2,349
Total operating expenses	62,650	34,243	166,125	89,626
Loss from operations	(34,933)	(33,677)	(105,825)	(86,892)
Interest expense	(1,646)	(1,687)	(4,933)	(5,044)
Interest and other income, net	564	82	1,748	504
Net loss	$ (36,015)	$ (35,282)	$ (109,010)	$ (91,432)
Net loss per common share, basic and diluted	$ (0.35)	$ (0.34)	$ (1.05)	$ (0.88)
Shares used in computing consolidated net loss per common share, basic and diluted	103,885	103,616	103,799	103,580
Unrealized gain on investments	$ (258)	$ (40)	$ 297	$ 121
Comprehensive loss	$ (36,273)	$ (35,322)	$ (108,713)	$ (91,311)