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Cash and Cash Equivalents and Investments (Details 1) - USD ($)
$ in Thousands
Sep. 30, 2016
Dec. 31, 2015
Cash and Cash Equivalents    
Fair Value    
Amortized Cost $ 38,772 $ 202,989
Gross Unrealized Gains 0 0
Gross Unrealized Losses 0 0
Estimated Fair Value 38,772 202,989
U.S. Treasury Securities    
Fair Value    
Amortized Cost 318,979 313,105
Gross Unrealized Gains 119 2
Gross Unrealized Losses (20) (219)
Estimated Fair Value 319,078 312,888
Corporate Debt Securities    
Fair Value    
Amortized Cost 37,727 5,477
Gross Unrealized Gains 5 0
Gross Unrealized Losses (26) (2)
Estimated Fair Value 37,706 5,475
Total Short-term Investments    
Fair Value    
Amortized Cost 356,706 318,582
Gross Unrealized Gains 124 2
Gross Unrealized Losses (46) (221)
Estimated Fair Value 356,784 318,363
Total Cash and Cash Equivalents and Investments    
Fair Value    
Amortized Cost 395,478 521,571
Gross Unrealized Gains 124 2
Gross Unrealized Losses (46) (221)
Estimated Fair Value $ 395,556 $ 521,352