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Cash and Cash Equivalents and Investments (Details 1) - USD ($)
$ in Thousands
Jun. 30, 2016
Dec. 31, 2015
Cash and Cash Equivalents    
Fair Value    
Amortized Cost $ 38,410 $ 202,989
Gross Unrealized Gains 0 0
Gross Unrealized Losses 0 0
Estimated Fair Value 38,410 202,989
U.S. Treasury Securities    
Fair Value    
Amortized Cost 379,307 313,105
Gross Unrealized Gains 333 2
Gross Unrealized Losses 0 (219)
Estimated Fair Value 379,640 312,888
Corporate Debt Securities    
Fair Value    
Amortized Cost 11,312 5,477
Gross Unrealized Gains 6 0
Gross Unrealized Losses (3) (2)
Estimated Fair Value 11,315 5,475
Total Short-term Investments    
Fair Value    
Amortized Cost 390,619 318,582
Gross Unrealized Gains 339 2
Gross Unrealized Losses (3) (221)
Estimated Fair Value 390,955 318,363
Total Cash and Cash Equivalents and Investments    
Fair Value    
Amortized Cost 429,029 521,571
Gross Unrealized Gains 339 2
Gross Unrealized Losses (3) (221)
Estimated Fair Value $ 429,365 $ 521,352