Income Taxes (Details 1) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Deferred Tax Assets and Liabilities
Deferred Tax Assets, Operating Loss Carryforwards	$ 263,138	$ 255,518
Deferred Tax Assets, Tax Credit Carryforwards, Research	43,728	40,173
Deferred Tax Assets, In Process Research and Development	85,385	95,946
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost	8,160	7,648
Deferred Tax Assets, Deferred Income	4,363	4,457
Deferred Tax Assets, Other	8,831	8,681
Deferred Tax Assets, Gross	413,605	412,423
Deferred Tax Liability Related to Acquisition of Symphony Icon	(18,675)	(18,675)
Deferred Tax Liabilities, Gross	(18,675)	(18,675)
Deferred Tax Assets, Valuation Allowance	(413,605)	(412,423)
Deferred Tax Liabilities, Net	$ (18,675)	$ (18,675)