Property and Equipment (Details 1) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Property, Plant and Equipment
Property, Plant and Equipment, Gross	$ 80,655	$ 37,354
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment	(59,428)	(36,274)
Property, Plant and Equipment, Net	21,227	1,080
Computers and Software
Property, Plant and Equipment
Property, Plant and Equipment, Gross	8,457	9,468
Furniture and Fixtures
Property, Plant and Equipment
Property, Plant and Equipment, Gross	6,269	7,032
Laboratory Equipment
Property, Plant and Equipment
Property, Plant and Equipment, Gross	3,908	12,737
Leasehold Improvements
Property, Plant and Equipment
Property, Plant and Equipment, Gross	240	8,117
Buildings
Property, Plant and Equipment
Property, Plant and Equipment, Gross	59,117	0
Land
Property, Plant and Equipment
Property, Plant and Equipment, Gross	$ 2,664	$ 0