Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenues:
Collaborative agreements	$ 129,728	$ 22,593	$ 2,109
Subscription and license fees	286	261	113
Total revenues	130,014	22,854	2,222
Operating expenses:
Research and development, including stock-based compensation of $3,693, $4,020 and $4,376, respectively	95,187	89,279	89,682
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability	5,927	1,428	(2,210)
General and administrative, including stock-based compensation of $3,150, $3,061 and $3,045, respectively	23,835	19,411	17,121
Impairment loss on buildings	3,597	13,102	0
Total operating expenses	128,546	123,220	104,593
Income (loss) from operations	1,468	(100,366)	(102,371)
Interest expense	(6,722)	(2,253)	(1,971)
Interest and other income, net	572	2,255	216
Consolidated net loss before taxes	(4,682)	(100,364)	(104,126)
Income tax benefit	0	70	0
Consolidated net loss	$ (4,682)	$ (100,294)	$ (104,126)
Consolidated net loss per common share, basic and diluted	$ (0.05)	$ (1.31)	$ (1.42)
Shares used in computing consolidated net loss per common share, basic and diluted	103,591	76,347	73,302
Other comprehensive loss:
Unrealized loss on investments	$ (156)	$ (65)	$ (21)
Comprehensive loss	$ (4,838)	$ (100,359)	$ (104,147)