Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2015	Sep. 30, 2014	Sep. 30, 2015	Sep. 30, 2014
Revenues:
Collaborative agreements	$ 505	$ 312	$ 2,635	$ 1,111
Subscription and license fees	61	107	99	261
Total revenues	566	419	2,734	1,372
Operating expenses:
Research and development, including stock-based compensation of $893, $797, $2,865 and $3,195, respectively	23,111	24,108	64,745	69,248
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability	3,404	(1,072)	5,145	518
General and administrative, including stock-based compensation of $779, $697, $2,548 and $2,389, respectively	5,379	4,617	17,387	15,423
Impairment loss on buildings	2,349	13,102	2,349	13,102
Total operating expenses	34,243	40,755	89,626	98,291
Loss from operations	(33,677)	(40,336)	(86,892)	(96,919)
Interest expense	(1,687)	(449)	(5,044)	(1,361)
Interest and other income, net	82	287	504	919
Consolidated net loss	$ (35,282)	$ (40,498)	$ (91,432)	$ (97,361)
Consolidated net loss per common share, basic and diluted	$ (0.34)	$ (0.55)	$ (0.88)	$ (1.32)
Shares used in computing consolidated net loss per common share, basic and diluted	103,616	73,542	103,580	73,494
Unrealized gain (loss) on investments	$ (40)	$ (3)	$ 121	$ 0
Comprehensive loss	$ (35,322)	$ (40,501)	$ (91,311)	$ (97,361)