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Consolidated Statements of Cash Flows (Unaudited) (USD $)
In Thousands, unless otherwise specified
3 Months Ended
Mar. 31, 2015
Mar. 31, 2014
Cash flows from operating activities:    
Consolidated net loss $ (28,076)us-gaap_NetIncomeLoss $ (30,835)us-gaap_NetIncomeLoss
Adjustments to reconcile consolidated net loss to net cash used in operating activities:    
Depreciation 355us-gaap_DepreciationDepletionAndAmortization 644us-gaap_DepreciationDepletionAndAmortization
Impairment of fixed assets 0us-gaap_ImpairmentOfLongLivedAssetsHeldForUse 242us-gaap_ImpairmentOfLongLivedAssetsHeldForUse
Increase in fair value of Symphony Icon, Inc. purchase liability 1,753lxrx_ChangeInFairValueOfSymphonyIconIncPurchaseLiability 1,142lxrx_ChangeInFairValueOfSymphonyIconIncPurchaseLiability
Stock-based compensation 1,953us-gaap_ShareBasedCompensation 2,250us-gaap_ShareBasedCompensation
Amortization of debt issuance costs 62us-gaap_AmortizationOfFinancingCostsAndDiscounts 0us-gaap_AmortizationOfFinancingCostsAndDiscounts
(Gain) loss on disposal of property and equipment 6us-gaap_GainLossOnSaleOfPropertyPlantEquipment (264)us-gaap_GainLossOnSaleOfPropertyPlantEquipment
Changes in operating assets and liabilities:    
Decrease in accounts receivable 865us-gaap_IncreaseDecreaseInAccountsReceivable 319us-gaap_IncreaseDecreaseInAccountsReceivable
(Increase) decrease in prepaid expenses and other current assets 1,570us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets (1,934)us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
(Increase) decrease in other assets (393)us-gaap_IncreaseDecreaseInOtherOperatingAssets 11us-gaap_IncreaseDecreaseInOtherOperatingAssets
Decrease in accounts payable and other liabilities (1,302)us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities (1,876)us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities
Decrease in deferred revenue (278)us-gaap_IncreaseDecreaseInDeferredRevenue (18)us-gaap_IncreaseDecreaseInDeferredRevenue
Net cash used in operating activities (23,485)us-gaap_NetCashProvidedByUsedInOperatingActivities (30,319)us-gaap_NetCashProvidedByUsedInOperatingActivities
Cash flows from investing activities:    
Purchases of property and equipment (17)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment (28)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment
Proceeds from disposal of property and equipment 4us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment 809us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment
Purchases of investments (70,978)us-gaap_PaymentsToAcquireInvestments (20,651)us-gaap_PaymentsToAcquireInvestments
Maturities of investments 0us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments 60,438us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments
Net cash provided by (used in) investing activities (70,991)us-gaap_NetCashProvidedByUsedInInvestingActivities 40,568us-gaap_NetCashProvidedByUsedInInvestingActivities
Cash flows from financing activities:    
Proceeds from issuance of common stock 0us-gaap_ProceedsFromIssuanceOfCommonStock 76us-gaap_ProceedsFromIssuanceOfCommonStock
Repurchase of common stock (357)us-gaap_PaymentsForRepurchaseOfCommonStock (887)us-gaap_PaymentsForRepurchaseOfCommonStock
Repayment of debt borrowings (456)us-gaap_RepaymentsOfLongTermDebt (420)us-gaap_RepaymentsOfLongTermDebt
Other financing activities (17)us-gaap_ProceedsFromPaymentsForOtherFinancingActivities 0us-gaap_ProceedsFromPaymentsForOtherFinancingActivities
Net cash used in financing activities (830)us-gaap_NetCashProvidedByUsedInFinancingActivities (1,231)us-gaap_NetCashProvidedByUsedInFinancingActivities
Net increase (decrease) in cash and cash equivalents (95,306)us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease 9,018us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease
Cash and cash equivalents at beginning of period 137,266us-gaap_CashAndCashEquivalentsAtCarryingValue 37,499us-gaap_CashAndCashEquivalentsAtCarryingValue
Cash and cash equivalents at end of period 41,960us-gaap_CashAndCashEquivalentsAtCarryingValue 46,517us-gaap_CashAndCashEquivalentsAtCarryingValue
Supplemental disclosure of cash flow information:    
Cash paid for interest 412us-gaap_InterestPaidNet 447us-gaap_InterestPaidNet
Supplemental disclosure of non-cash investing and financing activities:    
Unrealized gain on investments $ 86us-gaap_UnrealizedGainLossOnInvestments $ 8us-gaap_UnrealizedGainLossOnInvestments