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Consolidated Statements of Comprehensive Loss (Unaudited) (USD $)
In Thousands, except Per Share data, unless otherwise specified
3 Months Ended
Mar. 31, 2015
Mar. 31, 2014
Revenues:    
Collaborative agreements $ 1,792us-gaap_ContractsRevenue $ 172us-gaap_ContractsRevenue
Subscription and license fees 0us-gaap_LicensesRevenue 105us-gaap_LicensesRevenue
Total revenues 1,792us-gaap_Revenues 277us-gaap_Revenues
Operating expenses:    
Research and development, including stock-based compensation of $1,104 and $1,458, respectively 20,865us-gaap_ResearchAndDevelopmentExpense 23,953us-gaap_ResearchAndDevelopmentExpense
Increase in fair value of Symphony Icon, Inc. purchase liability 1,753lxrx_ChangeInFairValueOfSymphonyIconIncPurchaseLiability 1,142lxrx_ChangeInFairValueOfSymphonyIconIncPurchaseLiability
General and administrative, including stock-based compensation of $849 and $792, respectively 5,701us-gaap_GeneralAndAdministrativeExpense 5,654us-gaap_GeneralAndAdministrativeExpense
Total operating expenses 28,319us-gaap_OperatingExpenses 30,749us-gaap_OperatingExpenses
Loss from operations (26,527)us-gaap_OperatingIncomeLoss (30,472)us-gaap_OperatingIncomeLoss
Interest expense (1,702)us-gaap_InterestExpense (457)us-gaap_InterestExpense
Interest and other income, net 153us-gaap_OtherNonoperatingIncomeExpense 94us-gaap_OtherNonoperatingIncomeExpense
Consolidated net loss (28,076)us-gaap_NetIncomeLoss (30,835)us-gaap_NetIncomeLoss
Consolidated net loss per common share, basic and diluted $ (0.04)us-gaap_EarningsPerShareBasicAndDiluted $ (0.06)us-gaap_EarningsPerShareBasicAndDiluted
Shares used in computing consolidated net loss per common share, basic and diluted 724,613us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted 513,955us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted
Unrealized gain on investments 86us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax 8us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
Comprehensive loss $ (27,990)us-gaap_ComprehensiveIncomeNetOfTax $ (30,827)us-gaap_ComprehensiveIncomeNetOfTax