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Debt Obligations (Details) (USD $)
In Millions, except Per Share data, unless otherwise specified
1 Months Ended
Nov. 30, 2014
Apr. 30, 2004
Mar. 31, 2015
Dec. 31, 2014
Debt Instrument [Line Items]        
Proceeds from Convertible Debt $ 87.5us-gaap_ProceedsFromConvertibleDebt      
Convertible Debt Instrument Interest Rate Stated Percentage       5.25%lxrx_ConvertibleDebtInstrumentInterestRateStatedPercentage
Debt Instrument, Convertible, Conversion Ratio 829.1874us-gaap_DebtInstrumentConvertibleConversionRatio1      
Debt Instrument, Convertible, Conversion Price       $ 1.206us-gaap_DebtInstrumentConvertibleConversionPrice1
Debt Issuance Cost 3.4us-gaap_DebtIssuanceCosts      
Unamortized Debt Issuance Expense     3.2us-gaap_UnamortizedDebtIssuanceExpense  
Debt Instrument, Fair Value Disclosure     87.5us-gaap_DebtInstrumentFairValue  
Buildings Collateral     59.1lxrx_BuildingsCollateral  
Land Collateral     2.7lxrx_LandCollateral  
Mortgage Loans on Real Estate, New Mortgage Loans   34.0us-gaap_MortgageLoansOnRealEstateNewMortgageLoans    
Debt Instrument, Interest Rate, Stated Percentage     8.23%us-gaap_DebtInstrumentInterestRateStatedPercentage  
Mortgage Loans on Real Estate, Carrying Amount of Mortgages     $ 19.7us-gaap_MortgageLoansOnRealEstateCarryingAmountOfMortgages