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Equity Incentive Awards (Details 1) (USD $)
12 Months Ended
Dec. 31, 2014
Share-based Compensation Arrangement by Share-based Payment Award  
Stock Option Exercise Price as Percent of Value of Common Stock 100.00%lxrx_StockOptionExercisePriceAsPercentOfValueOfCommonStock
Restricted Stock Purchase Price as Percent of Value of Common Stock 85.00%lxrx_RestrictedStockPurchasePriceAsPercentOfValueOfCommonStock
Total Shares That May be Issued, Equity Incentive Plan 50,000,000lxrx_TotalSharesThatMayBeIssuedEquityIncentivePlan
Limit On Shares That May Be Issued Other Than Stock Options or SARs, Equity Incentive Plan 15,000,000lxrx_LimitOnSharesThatMayBeIssuedOtherThanStockOptionsOrSarsEquityIncentivePlan
Options Outstanding, Equity Incentive Plan 22,533,242lxrx_OptionsOutstandingEquityIncentivePlan
Restricted Stock Units Outstanding, Equity Incentive Plan 3,130,720lxrx_RestrictedStockUnitsOutstandingEquityIncentivePlan
Stock Options Exercised, Equity Incentive Plan 5,881,815lxrx_StockOptionsExercisedEquityIncentivePlan
Shares Issued Pursuant to Restricted Stock Units, Equity Incentive Plan 3,224,339lxrx_SharesIssuedPursuantToRestrictedStockUnitsEquityIncentivePlan
Shares Issued Pursuant to Stock Bonus Awards, Equity Incentive Plan 797,700lxrx_SharesIssuedPursuantToStockBonusAwardsEquityIncentivePlan
Directors Intial Option Grant 30,000lxrx_DirectorsIntialOptionGrant
Directors Annual Option Grant 20,000lxrx_DirectorsAnnualOptionGrant
Directors Annual Restricted Stock Award Value $ 20,000lxrx_DirectorsAnnualRestrictedStockAwardValue
Total Shares That May Be Issued, Non-Employee Directors Equity Incentive Plan 1,500,000lxrx_TotalSharesThatMayBeIssuedNonEmployeeDirectorsEquityIncentivePlan
Options Outstanding, Non-Employee Directors Equity Incentive Plan 1,070,000lxrx_OptionsOutstandingNonEmployeeDirectorsEquityIncentivePlan
Stock Options Exercised, Non-Employee Directors Equity Incentive Plan 0lxrx_StockOptionsExercisedNonEmployeeDirectorsEquityIncentivePlan
Shares Issued Pursuant to Restricted Stock Awards, Non-Employee Directors Equity Incentive Plan 277,480lxrx_SharesIssuedPursuantToRestrictedStockAwardsNonEmployeeDirectorsEquityIncentivePlan
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized 26,733,962us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant 14,584,704us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant