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Statements of Comprehensive Loss Parentheticals (Parentheticals) (USD $)
In Thousands, unless otherwise specified
 12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Stock-based compensation expense associated with research and development expense $ 4,020lxrx_StockBasedCompensationExpenseAssociatedWithResearchAndDevelopmentExpense $ 4,376lxrx_StockBasedCompensationExpenseAssociatedWithResearchAndDevelopmentExpense $ 3,673lxrx_StockBasedCompensationExpenseAssociatedWithResearchAndDevelopmentExpense
Stock-based compensation expense associated with general and administrative expense $ 3,061lxrx_StockBasedCompensationExpenseAssociatedWithGeneralAndAdministrativeExpense $ 3,045lxrx_StockBasedCompensationExpenseAssociatedWithGeneralAndAdministrativeExpense $ 2,822lxrx_StockBasedCompensationExpenseAssociatedWithGeneralAndAdministrativeExpense