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Income Taxes (Details 2) (USD $)
 12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Other Tax Information      
Revision to Deferred Tax Assets $ 13,800,000lxrx_RevisiontoDeferredTaxAssets    
Valuation Allowance, Deferred Tax Asset, Change in Amount 35,800,000us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount    
Operating Loss Carryforwards, Federal 715,800,000us-gaap_OperatingLossCarryforwards    
Operating Loss Carryforwards, State 460,200,000us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal    
Income Tax Expense (Benefit) $ (70,000)us-gaap_IncomeTaxExpenseBenefit $ 0us-gaap_IncomeTaxExpenseBenefit $ 0us-gaap_IncomeTaxExpenseBenefit