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Summary of Significant Accounting Policies Stock-Based Compensation (Details 1) (Stock Option)
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Stock Option
     
Share-based Compensation Arrangement by Share-based Payment Award      
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected VolatilityRate, Employees 66.00%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedvolatilityrateEmployees
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
85.00%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedvolatilityrateEmployees
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
93.00%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedvolatilityrateEmployees
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Employee 1.20%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateEmployee
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
0.90%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateEmployee
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
0.80%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateEmployee
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term, Employees 4 years 5 years 5 years
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate, Employees 0.00%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRateEmployees
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
0.00%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRateEmployees
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
0.00%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRateEmployees
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Officers and Non-employee Directors 80.00%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateOfficersAndNonEmployeeDirectors
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
81.00%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateOfficersAndNonEmployeeDirectors
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
81.00%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateOfficersAndNonEmployeeDirectors
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Officers and Non-employee Directors 2.30%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateOfficersAndNonEmployeeDirectors
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
1.60%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateOfficersAndNonEmployeeDirectors
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
1.50%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateOfficersAndNonEmployeeDirectors
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term, Officers and Non-employee Directors 8 years 8 years 8 years
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate, Officers and Non-employee Directors 0.00%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRateOfficersAndNonEmployeeDirectors
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
0.00%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRateOfficersAndNonEmployeeDirectors
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember
0.00%lxrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRateOfficersAndNonEmployeeDirectors
/ us-gaap_AwardTypeAxis
= us-gaap_StockOptionMember