<SEC-DOCUMENT>0001062822-14-000056-index.html : 20141205
<SEC-HEADER>0001062822-14-000056.hdr.sgml : 20141205
<ACCEPTANCE-DATETIME>20141204173625
ACCESSION NUMBER:		0001062822-14-000056
CONFORMED SUBMISSION TYPE:	S-3/A
PUBLIC DOCUMENT COUNT:		4
FILED AS OF DATE:		20141205
DATE AS OF CHANGE:		20141204

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC./DE
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-200699
		FILM NUMBER:		141267295

	BUSINESS ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3/A
<SEQUENCE>1
<FILENAME>s-3asymphonyshareissuance.htm
<DESCRIPTION>S-3/A
<TEXT>
Document 1 - file: s-3asymphonyshareissuance.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>exh51opinionofvinsonelkins.htm
<DESCRIPTION>EXHIBIT
<TEXT>
Document 2 - file: exh51opinionofvinsonelkins.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>exh231consentofernstyoungl.htm
<DESCRIPTION>EXHIBIT
<TEXT>
Document 3 - file: exh231consentofernstyoungl.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>logoa03.jpg
<DESCRIPTION>LOGO
<TEXT>
Document 4 - file: logoa03.jpg

</DOCUMENT>
</SEC-DOCUMENT>