Consolidated Statements of Comprehensive Loss (Unaudited) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2014	Sep. 30, 2013	Sep. 30, 2014	Sep. 30, 2013
Revenues:
Collaborative research	$ 312	$ 238	$ 1,111	$ 733
Subscription and license fees	107	0	261	79
Total revenues	419	238	1,372	812
Operating expenses:
Research and development, including stock-based compensation of $797, $1,027, $3,195 and $3,379, respectively	24,108	25,400	69,248	69,419
Increase (decrease) in fair value of Symphony Icon, Inc. purchase liability	(1,072)	1,338	518	3,079
General and administrative, including stock-based compensation of $697, $723, $2,389 and $2,349, respectively	4,617	4,716	15,423	13,709
Impairment loss on buildings	13,102	0	13,102	0
Total operating expenses	40,755	31,454	98,291	86,207
Loss from operations	(40,336)	(31,216)	(96,919)	(85,395)
Interest income	5	39	17	136
Interest expense	(449)	(492)	(1,361)	(1,494)
Other income, net	282	11	902	41
Consolidated net loss	(40,498)	(31,658)	(97,361)	(86,712)
Consolidated net loss per common share, basic and diluted	$ (0.08)	$ (0.06)	$ (0.19)	$ (0.17)
Shares used in computing consolidated net loss per common share, basic and diluted	514,796	513,419	514,461	512,980
Unrealized gain (loss) on investments	(3)	7	0	15
Comprehensive loss	$ (40,501)	$ (31,651)	$ (97,361)	$ (86,697)