Consolidated Statements of Comprehensive Loss (Unaudited) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended
	Mar. 31, 2014	Mar. 31, 2013
Revenues:
Collaborative research	$ 172	$ 284
Subscription and license fees	105	76
Total revenues	277	360
Operating expenses:
Research and development, including stock-based compensation of $1,458 and $1,330, respectively	23,953	20,327
Increase in fair value of Symphony Icon, Inc. purchase liability	1,142	1,264
General and administrative, including stock-based compensation of $792 and $779, respectively	5,654	4,324
Total operating expenses	30,749	25,915
Loss from operations	(30,472)	(25,555)
Interest income	8	53
Interest expense	(457)	(506)
Other income, net	86	34
Consolidated net loss	(30,835)	(25,974)
Consolidated net loss per common share, basic and diluted	$ (0.06)	$ (0.05)
Shares used in computing consolidated net loss per common share, basic and diluted	513,955	512,428
Unrealized gain on investments	8	19
Comprehensive loss	$ (30,827)	$ (25,955)