Income Taxes (Details 1) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012
Deferred Tax Assets and Liabilities
Document Period End Date	Dec. 31, 2013
Deferred Tax Assets, Operating Loss Carryforwards	$ 238,608	$ 216,579
Deferred Tax Assets, Tax Credit Carryforwards, Research	37,453	32,066
Deferred Tax Assets, In Process Research and Development	83,375	71,839
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost	7,703	12,972
Deferred Tax Assets, Deferred Income	4,760	4,906
Deferred Tax Assets, Other	4,712	10,429
Deferred Tax Assets, Gross	376,611	348,791
Deferred Tax Liability Related to Acquisition of Symphony Icon	(18,745)	(18,745)
Deferred Tax Liabilities, Other	0	(340)
Deferred Tax Liabilities, Gross	(18,745)	(19,085)
Deferred Tax Assets, Valuation Allowance	(376,611)	(348,451)
Deferred Tax Liabilities, Net	$ (18,745)	$ (18,745)