Property and Equipment (Details 1) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2013	Dec. 31, 2012
Property, Plant and Equipment
Property, Plant and Equipment, Gross	$ 123,307	$ 126,050
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment	(81,945)	(83,416)
Property, Plant and Equipment, Net	41,362	42,634
Computers and Software
Property, Plant and Equipment
Property, Plant and Equipment, Gross	11,180	11,042
Furniture and Fixtures
Property, Plant and Equipment
Property, Plant and Equipment, Gross	7,315	7,343
Laboratory Equipment
Property, Plant and Equipment
Property, Plant and Equipment, Gross	34,952	36,065
Leasehold Improvements
Property, Plant and Equipment
Property, Plant and Equipment, Gross	8,092	9,991
Buildings
Property, Plant and Equipment
Property, Plant and Equipment, Gross	59,104	58,945
Land
Property, Plant and Equipment
Property, Plant and Equipment, Gross	$ 2,664	$ 2,664