Income Taxes (Details) (USD $) In Thousands, unless otherwise specified	Dec. 31, 2012	Dec. 31, 2011
Deferred Tax Assets and Liabilities
Deferred Tax Assets, Operating Loss Carryforwards	$ 216,579	$ 195,810
Deferred Tax Assets, Tax Credit Carryforwards, Research	32,066	34,611
Deferred Tax Assets, In Process Research and Development	71,839	60,938
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost	12,972	11,843
Deferred Tax Assets, Deferred Income	4,906	5,008
Deferred Tax Assets, Other	10,429	7,126
Deferred Tax Assets, Gross	348,791	315,336
Deferred Tax Liability Related to Acquisition of Symphony Icon	(18,745)	(18,745)
Deferred Tax Liabilities, Other	(340)	(343)
Deferred Tax Liabilities, Gross	(19,085)	(19,088)
Deferred Tax Assets, Valuation Allowance	(348,451)	(314,993)
Deferred Tax Liabilities, Net	$ (18,745)	$ (18,745)