Consolidated Statements of Comprehensive Loss (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Revenues:
Collaborative research	$ 783	$ 1,632	$ 4,191
Subscription and license fees	306	217	717
Total revenues	1,089	1,849	4,908
Operating expenses:
Research and development, including stock-based compensation of $3,673, $3,249 and $3,170, respectively	82,574	91,828	78,520
Increase in fair value of Symphony Icon, Inc. purchase liability	9,887	6,766	2,710
General and administrative, including stock-based compensation of $2,822, $2,458 and $2,308, respectively	17,043	17,350	19,396
Total operating expenses	109,504	115,944	100,626
Loss from operations	(108,415)	(114,095)	(95,718)
Gain on investments, net	0	0	141
Interest income	213	255	519
Interest expense	(2,114)	(2,528)	(2,719)
Other income (expense), net	105	153	(4,024)
Consolidated net loss before taxes	(110,211)	(116,215)	(101,801)
Income tax benefit	0	0	26
Consolidated net loss	(110,211)	(116,215)	(101,775)
Consolidated net loss per common share, basic and diluted	$ (0.23)	$ (0.34)	$ (0.34)
Shares used in computing consolidated net loss per common share, basic and diluted	489,707	340,761	302,844
Other comprehensive gain (loss):
Unrealized gain on investments	2	16	5
Comprehensive loss	$ (110,209)	$ (116,199)	$ (101,770)