Exhibit 23.1

We consent to the incorporation by reference in the Registration Statement Form S-8 pertaining to the Equity Incentive Plan and the Non-Employee Directors' Equity Incentive Plan of our reports dated March 7, 2012, with respect to the consolidated financial statements of Lexicon Pharmaceuticals, Inc. and the effectiveness of internal control over financial reporting of Lexicon Pharmaceuticals, Inc., included in its Annual Report (Form 10-K) for the year ended December 31, 2011, filed with the Securities and Exchange Commission.