Consolidated Statements of Comprehensive Loss (Unaudited) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012	Jun. 30, 2011
Revenues:
Collaborative research	$ 199	$ 461	$ 351	$ 977
Subscription and license fees	0	94	148	174
Total revenues	199	555	499	1,151
Operating expenses:
Research and development, including stock-based compensation of $915, $818, $1,952 and $1,657, respectively	19,355	20,145	42,392	44,066
Increase in fair value of Symphony Icon, Inc. purchase liability	2,162	1,804	4,243	2,862
General and administrative, including stock-based compensation of $680, $632, $1,361 and $1,265, respectively	4,162	4,532	8,727	9,285
Total operating expenses	25,679	26,481	55,362	56,213
Loss from operations	(25,480)	(25,926)	(54,863)	(55,062)
Interest income	58	68	114	155
Interest expense	(530)	(810)	(1,067)	(1,417)
Other income, net	21	30	17	57
Consolidated net loss	(25,931)	(26,638)	(55,799)	(56,267)
Consolidated net loss per common share, basic and diluted	$ (0.05)	$ (0.08)	$ (0.12)	$ (0.17)
Shares used in computing consolidated net loss per common share, basic and diluted	480,634	337,668	480,479	337,598
Unrealized gain (loss) on investments	37	31	(41)	66
Comprehensive loss	$ (25,894)	$ (26,607)	$ (55,840)	$ (56,201)