Consolidated Statements of Comprehensive Loss (Unaudited) (USD $) In Thousands, except Per Share data, unless otherwise specified	3 Months Ended
	Mar. 31, 2012	Mar. 31, 2011
Revenues:
Collaborative research	$ 152	$ 516
Subscription and license fees	148	80
Total revenues	300	596
Operating expenses:
Research and development, including stock-based compensation of $1,037 and $839, respectively	23,037	23,921
Increase in fair value of Symphony Icon, Inc. purchase liability	2,081	1,058
General and administrative, including stock-based compensation of $681 and $633, respectively	4,565	4,753
Total operating expenses	29,683	29,732
Loss from operations	(29,383)	(29,136)
Interest income	56	87
Interest expense	(537)	(607)
Other income (expense), net	(4)	27
Consolidated net loss	(29,868)	(29,629)
Consolidated net loss per common share, basic and diluted	$ (0.06)	$ (0.09)
Shares used in computing consolidated net loss per common share, basic and diluted	480,324	337,527
Unrealized gain (loss) on investments	(78)	35
Comprehensive loss	$ (29,946)	$ (29,594)