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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 rd+ZBCNnH66/4He9HPxyVw==

<SEC-DOCUMENT>0001062822-10-000025.txt : 20100331
<SEC-HEADER>0001062822-10-000025.hdr.sgml : 20100331
<ACCEPTANCE-DATETIME>20100331105603
ACCESSION NUMBER:		0001062822-10-000025
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100331
DATE AS OF CHANGE:		20100331
EFFECTIVENESS DATE:		20100331

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LEXICON PHARMACEUTICALS, INC./DE
		CENTRAL INDEX KEY:			0001062822
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				760474169
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-140077
		FILM NUMBER:		10717037

	BUSINESS ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		2818633000

	MAIL ADDRESS:	
		STREET 1:		8800 TECHNOLOGY FOREST PLACE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LEXICON GENETICS INC/TX
		DATE OF NAME CHANGE:	20000126
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
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        <entityName>LEXICON PHARMACEUTICALS, INC./DE</entityName>
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            <street1>8800 TECHNOLOGY FOREST PLACE</street1>
            <city>THE WOODLANDS</city>
            <stateOrCountry>TX</stateOrCountry>
            <zipCode>77381</zipCode>
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                <city>The Woodlands</city>
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                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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                <firstName>Alan</firstName>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
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                <firstName>Samuel</firstName>
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            <relatedPersonRelationshipList>
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                <lastName>Amouyal</lastName>
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                <firstName>Raymond</firstName>
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            <relatedPersonName>
                <firstName>Robert</firstName>
                <middleName>J</middleName>
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                <zipCode>77381</zipCode>
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            <relatedPersonRelationshipList>
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            <relatedPersonName>
                <firstName>Alan</firstName>
                <middleName>S</middleName>
                <lastName>Nies</lastName>
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        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$5,000,001 - $25,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
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        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-03-19</value>
            </dateOfFirstSale>
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        <durationOfOffering>
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        <typesOfSecuritiesOffered>
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        <businessCombinationTransaction>
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        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
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            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
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        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
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        <salesCommissionsFindersFees>
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        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
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                <issuerName>LEXICON PHARMACEUTICALS, INC./DE</issuerName>
                <signatureName>/s/ Jeffrey L. Wade</signatureName>
                <nameOfSigner>Jeffrey L. Wade</nameOfSigner>
                <signatureTitle>Executive Vice President and General Counsel</signatureTitle>
                <signatureDate>2010-03-31</signatureDate>
            </signature>
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</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----